dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000396 |
| Uniprot Accession | O08914; FAAH1_MOUSE; Q922S0; Q9DBF5; |
| Genbank Protein ID | NP_034303.3; |
| Genbank Nucleotide ID | NM_010173.4; |
| Protein Name | Fatty-acid amide hydrolase 1 |
| Protein Synonyms/Alias | Anandamide amidohydrolase 1;Oleamide hydrolase 1; |
| Gene Name | Faah |
| Gene Synonyms/Alias | Faah1; |
| Organism | Mus musculus(Mouse) |
| NCBI Taxa ID | 10090 |
| Functional Description (View all) |
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MVLSEVWTAL SGLSGVCLAC SLLSAAVVLR WTRSQTARGA VTRARQKQRA GLETMDKAVQ 60 RFRLQNPDLD SEALLALPLL QLVQKLQSGE LSPEAVLFTY LGKAWEVNKG TNCVTSYLTD 120 CETQLSQAPR QGLLYGVPVS LKECFSYKGH ASTLGLSLNE GVTSESDCVV VQVLKLQGAV 180 PFVHTNVPQS MLSYDCSNPL FGQTMNPWKP SKSPGGSSGG EGALIGSGGS PLGLGTDIGG 240 SIRFPSAFCG ICGLKPTGNR LSKSGLKSCV YGQTAVQLSV GPMARDVDSL ALCMKALLCE 300 DLFRLDSTIP PLPFREEIYR SSRPLRVGYY ETDNYTMPTP AMRRAVMETK QSLEAAGHTL 360 VPFLPNNIPY ALEVLSAGGL FSDGGCSFLQ NFKGDFVDPC LGDLVLVLKL PRWFKKLLSF 420 LLKPLFPRLA AFLNSMCPRS AEKLWELQHE IEMYRQSVIA QWKAMNLDVV LTPMLGPALD 480 LNTPGRATGA ISYTVLYNCL DFPAGVVPVT TVTAEDDAQM EHYKGYFGDM WDNILKKGMK 540 KGIGLPVAVQ CVALPWQEEL CLRFMREVER LMTPEKRPS |
| Keyword | KW-0181--Complete proteome |
| Interpro | IPR000120--Amidase |
| PROSITE | PS00571--AMIDASES |
| Pfam | PF01425--Amidase |
| Gene Ontology | GO:0005789--C:endoplasmic reticulum membrane |