dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000391
Uniprot Accession O08900; IKZF3_MOUSE; B1AQE6;
Genbank Protein ID NP_035901.1;
Genbank Nucleotide ID NM_011771.1;
Protein Name Zinc finger protein Aiolos
Protein Synonyms/Alias Ikaros family zinc finger protein 3;
Gene Name Ikzf3
Gene Synonyms/Alias Zfpn1a3;Znfn1a3;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
7-MEDIQPTVELKSTEdbPTM 3.0;PhosphoSitePlus;curated19367708; 16381945; 23193290; 22135298; 22817900
20TEEQPLPTESPDALNdbPTM 3.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 22135298; 22817900
22EQPLPTESPDALNDYdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 25266776;
42HEIENVDSREAPANEdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
65MKVKDEYSDRDENIMcurated21183079
138VLMVHKRSHTGERPFcurated25266776
140MVHKRSHTGERPFQCcurated25266776
214GRSYKQRSSLEEHKEPhosphoSitePlus22135298
215RSYKQRSSLEEHKERPhosphoSitePlus22135298
237PDLGDAASVEARHIKcurated25266776
260LVLDRLASNVAKRKSPhosphoSitePlus22135298
267SNVAKRKSSMPQKFIcurated25266776
325ALRPLVQTPPAPTSEPhosphoSitePlus22135298
377LPSERGLSPNNSAQDdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
385PNNSAQDSTDTDSNHdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
388SAQDSTDTDSNHEDRPhosphoPep 2.019060867
390QDSTDTDSNHEDRQHdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MEDIQPTVEL KSTEEQPLPT ESPDALNDYS LPKPHEIENV DSREAPANED EDAGEDSMKV 60
KDEYSDRDEN IMKPEPMGDA EESEMPYSYA REYSDYESIK LERHVPYDNS RPTGGKMNCD 120
VCGLSCISFN VLMVHKRSHT GERPFQCNQC GASFTQKGNL LRHIKLHTGE KPFKCHLCNY 180
ACQRRDALTG HLRTHSVEKP YKCEFCGRSY KQRSSLEEHK ERCRAFLQNP DLGDAASVEA 240
RHIKAEMGSE RALVLDRLAS NVAKRKSSMP QKFIGEKRHC FDANYNPGYM YEKENEMMQT 300
RMMDQAINNA ISYLGAEALR PLVQTPPAPT SEMVPVISSV YPIALTRADM PNGAPQEMEK 360
KRILLPEKIL PSERGLSPNN SAQDSTDTDS NHEDRQHLYQ QSHVVLPQAR NGMPLLKEVP 420
RSFELLKPPP ICLRDSIKVI NKEGEVMDVF RCDHCHVLFL DYVMFTIHMG CHGFRDPFEC 480
NMCGYRSHDR YEFSSHIARG EHRAMLK 508
Keyword

KW-0075--B-cell activation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00096--zf-C2H2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0042113--P:B cell activation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042981--P:regulation of apoptotic process
GO:0045577--P:regulation of B cell differentiation
GO:0030888--P:regulation of B cell proliferation
GO:0045619--P:regulation of lymphocyte differentiation
GO:0006366--P:transcription from RNA polymerase II promoter