dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000390
Uniprot Accession O08899; RGS4_MOUSE; Q99L30;
Genbank Protein ID NP_033088.2;
Genbank Nucleotide ID NM_009062.3;
Protein Name Regulator of G-protein signaling 4
Protein Synonyms/Alias
Gene Name Rgs4
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
108IKSPSKLSPKAKKIYPhosphoSitePlus22135298
Sequence
(Fasta)
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR VSQEEVKKWA 60
ESLENLIHHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS 120
VQATKEVNLD SCTREETSRN MLQPTITCFD EAQKKIFNLM ERDSYRRFLK SRFYLDLTNP 180
SSCGAEKQKG AKSSADCTSL VSQCA 206
Keyword

KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0734--Signal transduction inhibitor

Interpro

IPR016137--RGS
IPR024066--RGS_subdom1

PROSITE

PS50132--RGS

Pfam

PF00615--RGS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0009968--P:negative regulation of signal transduction
GO:0043547--P:positive regulation of GTPase activity