| Tag |
Content |
| dbPAF ID |
dbPAF-0000388 |
| Uniprot Accession |
O08876; KLF10_RAT; Q4QRA4;
|
| Genbank Protein ID |
NP_112397.1;
|
| Genbank Nucleotide ID |
NM_031135.2;
|
| Protein Name |
Krueppel-like factor 10 |
| Protein Synonyms/Alias |
Transforming growth factor-beta-inducible early growth response protein 1;TGFB-inducible early growth response protein 1;TIEG-1;Zinc finger transcription factor homolog CPG20; |
| Gene Name |
Klf10 |
| Gene Synonyms/Alias |
Cpg20;Tieg;Tieg1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.Functional Description
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 248 | RSSQPAPTSPVQKSV | curated | 23984901 |
|
Sequence
(Fasta) | MLNFGASLQQ ASEGKMELIS EKSKEGAHPW DKAEQSDFEA VEALMSMSCD WKSHFKKYLE 60
NRPVTPVSDT SEEDSLLPGT PDLQTVPAFC LTPPYSPSDF EPSQGSNLTA PAPPTGHFRS 120
LSDAAKPPSI APFKEEEKSP LAAPPLPKAQ ATSVIRHTAD AQLCNHQSCP VKAASILNYQ 180
DNSFRRRTHI NVEATRKNIP CAAVSPNRPK PEPSTAANGA EKAGTAPYDF AVPSSETVIC 240
RSSQPAPTSP VQKSVLMSSP TVSTGGVPPL PVICQMVPLP ANNSLVTTVV PSSPPSQPPA 300
VCSPVLFMGT QVPKGTVMFV VPQPVVQSPK PPVVSPNGTR LSPIAPAPGF SPSAARVTPQ 360
IDSSRVRSHI CSHPGCGKTY FKSSHLKAHV RTHTGEKPFS CSWKGCERRF ARSDELSRHR 420
RTHTGEKKFA CPMCDRRFMR SDHLTKHARR HLSAKKLPNW QMEVSKLNDI ALPPATASAQ 480
481Fasta Sequence
>O08876|Klf10|Rattus norvegicus(Rat)
MLNFGASLQQASEGKMELISEKSKEGAHPWDKAEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEEDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTAPAPPTGHFRSLSDAAKPPSIAPFKEEEKSPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHINVEATRKNIPCAAVSPNRPKPEPSTAANGAEKAGTAPYDFAVPSSETVICRSSQPAPTSPVQKSVLMSSPTVSTGGVPPLPVICQMVPLPANNSLVTTVVPSSPPSQPPAVCSPVLFMGTQVPKGTVMFVVPQPVVQSPKPPVVSPNGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPATASAQ
|
| Keyword |
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
|
| PROSITE |
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0046872--F:metal ion binding
GO:0030282--P:bone mineralization
GO:1901653--P:cellular response to peptide
GO:0009267--P:cellular response to starvation
GO:0007623--P:circadian rhythm
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0042752--P:regulation of circadian rhythm
GO:0035019--P:somatic stem cell population maintenance
GO:0006351--P:transcription, DNA-templated
|
