dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000387
Uniprot Accession O08875; DCLK1_RAT;
Genbank Protein ID NP_445795.1;
Genbank Nucleotide ID NM_053343.3;
Protein Name Serine/threonine-protein kinase DCLK1
Protein Synonyms/Alias Calcium/calmodulin-dependent protein kinase type I-like CPG16;Doublecortin-like and CAM kinase-like 1;Doublecortin-like kinase 1;
Gene Name Dclk1
Gene Synonyms/Alias Cpg16;Dcamkl1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
23STPRSGKSPSPSPTSPhosphoSitePlus;curated22135298; 24945867
25PRSGKSPSPSPTSPGPhosphoSitePlus;UniProt;curated22135298; 22673903; 21630457; 24945867
27SGKSPSPSPTSPGSLcurated21630457; 24945867
29KSPSPSPTSPGSLRKcurated21630457
30SPSPSPTSPGSLRKQdbPTM 3.0;PhosphoSitePlus;UniProt19054758; 16381945; 23193290; 22135298; 22673903
45RISQHGGSSTSLSSTPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
46ISQHGGSSTSLSSTKPhosphoSitePlus;UniProt22135298; 22673903
48QHGGSSTSLSSTKVCPhosphoSitePlus22135298
57SSTKVCSSMDENDGPPhosphoSitePlus22135298
186RDASGMLYNLASAIKPhosphoSitePlus22135298
213KPENLLVYEHQDGSKPhosphoSitePlus22135298
369FNTGPKPSSTAAGVSdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
370NTGPKPSSTAAGVSVdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
371TGPKPSSTAAGVSVIdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
376SSTAAGVSVIATTALdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
380AGVSVIATTALDKERdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
419NSESEDYSPSSSETVPhosphoSitePlus;UniProt22135298; 22673903
Sequence
(Fasta)		MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS STKVCSSMDE 60
NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC IERSTAREYA LKIIKKSKCR 120
GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTSKYTERD 180
ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV 240
CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD 300
FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK 360
HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG RYKAQPAPPE LNSESEDYSP 420
SSSETVRSPN SPF 434
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0418--Kinase
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR020636--Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
Gene Ontology

GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0030154--P:cell differentiation
GO:0007399--P:nervous system development
GO:0006468--P:protein phosphorylation