dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000382
Uniprot Accession O08856; ELL_MOUSE; Q3TXY9;
Genbank Protein ID NP_031950.2;
Genbank Nucleotide ID NM_007924.2;
Protein Name RNA polymerase II elongation factor ELL
Protein Synonyms/Alias Eleven-nineteen lysine-rich leukemia protein;
Gene Name Ell
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (By similarity). Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
133SYQKARQSMAQAEEEdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
296LCQPQNATTDSSPPRcurated25266776
297CQPQNATTDSSPPREcurated25266776; 23984901
299PQNATTDSSPPREHGPhosphoSitePlus;curated22135298; 25266776; 25338131
300QNATTDSSPPREHGRdbPTM 3.0;PhosphoSitePlus;curated20139300; 16381945; 23193290; 22135298; 25266776; 21743459;
308PPREHGRSASPSQKRcurated23984901
310REHGRSASPSQKRPTPhosphoSitePlus;curated22135298; 25266776; 25338131
312HGRSASPSQKRPTDFcurated25266776
317SPSQKRPTDFIDPLAPhosphoSitePlus22135298
Sequence
(Fasta)		MAALKEARSY GLSCGRVSDG SRVSVFHVKL TDSALKAFES YRAHQDSVSL RPSIRFEGSQ 60
GHISIPQPDC PEEVRAFSFY LSNIGRDSPQ GSFDCIQQYV SSYGDVHLDC LGSIQDKVTV 120
CATDDSYQKA RQSMAQAEEE TRSRSAIVIK AGGRYMGKKV QFRKPAPGAA DAVPSRKRAT 180
PINLASAIRK SSGSGASSVV QRPFRDRVLH LLALRPYRKA ELLLRLQKDG LTQADKDTLD 240
SLLQQVASVN PKDGTCTLQD CMYKSLQKDW PGYSEGDRQL LKRMLMRKLC QPQNATTDSS 300
PPREHGRSAS PSQKRPTDFI DPLASKKPRI SHFTQRAQPT LNGKLGAPNG HETLLPAPGP 360
TPSDTLSSSH LPPRLEPPRT HDPLADVSND LGHSTQDYKH QEATPAPAPH LGLPLLTDFP 420
QAEQPTSSSH THSRPKKKSK KHKDKERPPE ERPPAPQPDA PTAPALPPDA PGLNGACDNE 480
PTSSSETPDY LLKYPAISSS EQRQSYKNDF NAEYSEYRSL HARIEQITRR FTQLDAQLRQ 540
LSQGSDEYET TRGQILQEYR KIKKTNTNYS CEKRRCEYLH RKLAHIKRLI AEYDQRQLQA 600
WP 603
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR031184--ELL
IPR031176--ELL/occludin
IPR019464--ELL_N
IPR010844--Occludin_ELL
IPR011991--WHTH_DNA-bd_dom
PROSITE
Pfam

PF10390--ELL
PF07303--Occludin_ELL
Gene Ontology

GO:0015030--C:Cajal body
GO:0035363--C:histone locus body
GO:0016607--C:nuclear speck
GO:0008023--C:transcription elongation factor complex
GO:0035327--C:transcriptionally active chromatin
GO:0019902--F:phosphatase binding
GO:0001701--P:in utero embryonic development
GO:0010923--P:negative regulation of phosphatase activity
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045945--P:positive regulation of transcription from RNA polymerase III promoter
GO:0042795--P:snRNA transcription from RNA polymerase II promoter
GO:0042796--P:snRNA transcription from RNA polymerase III promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter