dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000381
Uniprot Accession O08852; PKD1_MOUSE; E9QJR6;
Genbank Protein ID NP_038658.2;
Genbank Nucleotide ID NM_013630.2;
Protein Name Polycystin-1
Protein Synonyms/Alias Autosomal dominant polycystic kidney disease 1 protein homolog;
Gene Name Pkd1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
2333LEAGVEYTFNLIVWKPhosphoSitePlus22135298
2715ADSILNITGDLIHLAPhosphoSitePlus22135298
2808FSIPEAFSGALSNLSPhosphoSitePlus22135298
3623EDDTLVESPAVTPVScurated25338131
4159PSRSSRGSKSSPVVLdbPTM 3.0;PhosphoSitePlus;curated10364454; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MPLGAPALLA LALGLGLWLG ALAGDPGRGC GPCPLPCFCG PAPDAACRVN CSGRWLQTLG 60
PSLRIPADAT ALDLSHNLLQ TLDIGLLVNL SALVELDLSN NRISTLEEGV FANLFNLSEI 120
NLSGNPFECN CGLAWLPRWA KEHQVHVVQS EATTCRGPIP LAGQPLLSIP LLDNACGEEY 180
VACLPDNSSG AVAAVPFYFA HEGPLETEAC SAFCFSAGEG LAALSEQNQC LCGAGQASNS 240
SAACSSWCSS ISLSLNSACG GPTLLQHTFP ASPGATLVGP HGPLASGQPA DFHITSSLPI 300
SSTRWNFGDG SPEVDMASPA ATHFYVLPGS YHMTVVLALG AGSALLETEV QVEATPTVLE 360
LVCPSFVHSN ESLELGIRHR GGSALEVTYS ILALDKEPAQ VVHPLCPLDT EIFPGNGHCY 420
RLVAEKAPWL QAQEQCRTWA GAALAMVDSP AIQHFLVSKV TRSLDVWIGF SSVEGTEGLD 480
PRGEAFSLES CQNWLPGEPH PATAEHCVRL GPAGQCNTDL CSAPHSYVCE LRPGGPVWDT 540
ENFVMGMSGG GLSGPLHPLA QQETVQGPLR PVEVMVFPGL SPSREAFLTA AEFSTQKLEE 600
PAQMRLQVYR PSGGAAAVPE GSSEPDNRTE PAPKCVPEEL WCPGANVCIP FDASCNSHVC 660
INGSVSRLGL SRASYTLWKE FFFSVPAGPP TQYLVTLHSQ DVPMLPGDLI GLQHDAGPGT 720
LLQCPLASSC PGQALYLSTN ASDWMTNLPV HLEEAWAGPV CSLQLLLVTE RLTPLLGLGP 780
NPGLQHPGHY EVRATVGNSV SRQNLSCSFS VVSPIAGLRV IHPIPLDGHI YVPTNGSVLV 840
LQVDSGANAT ATAQWFGGNI SAPFEDACPP EVDFLKQDCT EEANGTLFSV LMLPRLKEGD 900
HTVEIVAQNG ASQANLSLRV TAEEPICGLR AVPSPEARVL QGILVRYSPM VEAGSDVAFR 960
WTIDDKQSLT FHNTVFNVIY QSAAIFKLSL TASNHVSNIT VNYNVTVERM NKMHGLWVSA 1020
VPTVLPPNAT LALTGGVLVD SAVEVAFLWN FGDGEQVLRQ FKPPYDESFQ VPDPTVAQVL 1080
VEHNTTHIYT TPGEYNLTVL VSNTYENLTQ QVTVSVRTVL PNVAIGMSSN VLVAGQPITF 1140
SPYPLPSTDG VLYTWDFGDG SPVLIQSQPV LNHTYSMTGA YRITLEVNNT VSSVTAHADI 1200
RVFQELHGLT VYLSPSVEQG APMVVSASVE SGDNITWTFD MGDGTVFTGP EATVQHVYLR 1260
AQNFTVTVEA ANPAGHLSQS LHVQVFVLEV LHIEPSTCIP TQPSAQLMAH VTGDPVHYLF 1320
DWTFGDGSSN VTVHGHPSVT HNFTRSGIFP LALVLSSHVN KAHYFTSICV EPEIRNITLQ 1380
PERQFVKLGD EARLVAYSWP PFPYRYTWDF GTEDTTHTQT GGSEVKFIYR EPGSYLVIVT 1440
VSNNISSTND SAFVEVQEPV LVTGIRINGS HVLELQQPYL LSAMGSGSPA TYLWELGDGS 1500
QSEGPEVTHI YSSTGDFTVR VSGWNEVSRS EAQLNITVKQ RVRGLTINAS RTVVPLNGSV 1560
SFSTLLEVGS DVHYSWVLCD RCTPIPGGPT ISYTFRSVGT FNIIVTAENE VGSAQDSIFI 1620
YVLQFIEGLQ VAGGDNGCCF PTNYTLQLQA AVRDGTNISY SWTAQQEGSL ITLFGSGKCF 1680
SLTSLKASTY YVHLRATNML GSAAANRTID FVEPVESLIL SASPNPAAVN MSLTLCAELA 1740
GGSGVVYTWY LEEGLSWKTS MPSTTHTFAA PGLHLVRVTA ENQLGSVNAT VEVAIQVPVG 1800
GLSIRTSEPD SIFVAAGSTL PFWGQLAEGT NVTWCWTLPG GSKDSQYIAV RFSTAGSFSL 1860
QLNASNAVSW VSAMYNLTVE EPIVNLMLWA SSKVVAPGQP VHFEILLAAG SALTFRLQVG 1920
GSVPEVLPSP HFSHSFFRVG DHLVNVQAEN HVSHAQAQVR ILVLEAVVGL QVPNCCEPGM 1980
ATGTEKNFTA RVQRGSRVAY AWYFSLQKVQ GDSLVILSGR DVTYTPVAAG LLEIHVRAFN 2040
ELGGVNLTLM VEVQDIIQYV TLQSGRCFTN RSARFEAATS PSPRRVTYHW DFGDGTPVQK 2100
TEEFWADHYY LRPGDYHVEV NATNLVSFFV AQATVTVQVL ACREPEVEVA LPLQVLMRRS 2160
QRNYLEAHVD LRNCVSYQTE YRWEIYRTAS CQRPGRMAQM VLPGVDVSRP QLVVPRLALP 2220
VGHYCFVFVV SFGDTPLARS IQANVTVAAE RLVPIIEGGS YRVWSDTQDL VLDGSKSYDP 2280
NLEDGDQTPL NFHWACVAST QSETGGCVLN FGPRGSSVVT IPLERLEAGV EYTFNLIVWK 2340
AGRKEEATNQ TVLIRSGRVP IVSLECVSCK AQAVYEVSRS SYVYLEGHCH NCSRGYKQGC 2400
WAARTFSNKT LVLNETTTST GSTGMNLVVR PGALRDGEGY IFTLTVLGHS GEEEGCASIR 2460
LSPNRPPLGG SCRLFPLDSV RGLTTKVHFE CTGWRDAEDG GAPLVYALLL KRCRQSYCEN 2520
FCIYKGSLST YGAVLPPGFQ PLFVVSLAVV VQDQLGAAVV ALNRSLTIVL PEPSGNPADL 2580
VPWLHSLTAS VLPGLLKQAD PQHVIEYSLA LITVLNEYEQ APDVSEPNVE QQLRAQMRKN 2640
ITETLISLRV NTVDDIQQIT AALAQCMVSS RELMCRSCLK KMLQKLEGMM RILQAETTEG 2700
TLTPTTIADS ILNITGDLIH LASLDMQGPQ PLELGVEPPS LMVASKAYNL SSALMRILMR 2760
SRVLNEEPLT LAGEEIVALG KRSDPLSLLC YGKALGPSCH FSIPEAFSGA LSNLSDVVQL 2820
IFLVDSNPFP FGYISNYTVS TKVASMAFQT QTGTQIPIEQ LAAERAITVK VPNNSDQAAQ 2880
SSHNPVGSTI VQPQTSVSAV VTADNSNPQA GLHLRITYTV LNERYLSAEP EPYLAVYLHS 2940
VSQPNEYNCS ASRRISLEVL EGADHRLYTF FIAPGTGTLD RSYYLNLTSH FHWSALEVSV 3000
GLYTSLCQYF SEEMMMWRTE GIVPLEETSP SQAVCLTRHL TAFGASLFVP PSHVQFIFPE 3060
PSASINYIVL LTCVICLVTY VVMAMILRKL DQLDVSRVRV IPFCGKGGRF KYEILVKTGW 3120
SRGSGTTAHV GIMLYGEDNR SGHRHLDGDR AFHRNSLDIF QIATPHSLGS VWKIRVWHDN 3180
KGLSPAWFLQ HIIVRDLQSA RSTFFLVNDW LSVETEANGG LVEKEVLAAN EAALWQFQRL 3240
LVAELQRGFF DKHIWLSIWD RPPRSRFTRV QRVTCCVLLL CLFLAANAVW YGVVRDTTYS 3300
MGPVSSLISP GVDTVAIGLV SSVVVYPVYL AVLFLFRMSR SKVSGDQNPT PTGQQALDVD 3360
SYLDPSVLDS SLLTLSGLTE AFAGQVKNDL FLEDAKSLVC WPSSEGTLSW PDLLSDPSVV 3420
SSTLQRLTQG RPGCMLGSEE DGASLVSPSL PAKYLSASDE DLIHQVLADG ANNLVPTQDT 3480
LLETDLLTSL SSVPGEKTET LILQTVGEER PASMGLSWEQ SPVTRLSRTG LVEGFQKRLL 3540
PAWCAPLAHG LSLLLVAVAV AVSGWIGASF PPSVSVMWLL SSSSSFLASF LGWEPLKVLL 3600
EALYFSLVAK RLHPDEDDTL VESPAVTPVS ERVPRVRPPH GFALFLAKEE ARKVKRLHDM 3660
LKRLLVYMLF LLVTLLANYG DASCHGHAYR LQSAIKQELD SQAFLAITRS DEFWPWMSHV 3720
FLPYVHGNQS SPELGPPRLR QVRLQEAFCP DPSSSEHMCS AAGSLSTSDY GIGWQSVVQN 3780
GSETWAYSAP DLLGAWYWGY CAVYDSGGYI QELGLSLEES RARLGFLQLH NWLDSRSRAV 3840
FVELTRYSPA VGLHAAVTLR LEFPVAGHAL AAFSVRPFAL RRLSTGLSLP LLTSVCLLLF 3900
ALYFSMAEVQ TWRKDGCACT ARPDTWARCL LVILTAATGL VRLAQLGIAD RQWTHFVQDH 3960
PRHFTSFDQV AQLGSVARGL AASLLFLLLV KAAQQLRFVR QWSVFGKTLC RALPELMGAT 4020
LGLVLLGVAY AQMAILLISS GADTLYNMAR AFLVLCPGAR VPTLCPSESW YLSPLLCVGL 4080
WALRVWGALR LGAILLRWRY HALRGELYRP AWEPQDYEMV ELFLRRLRLW MGFSKVKEFR 4140
HKVRFEGMDP LPSRSSRGSK SSPVVLPPSS GSEASHPSTS SSQPDGPSAS LSRSTLKLEP 4200
EPSRLHAVFE SLLVQFDRLN QATEDVYQLE QQLQSLQGHG HNGPPSSPSP GCFPGSQPAL 4260
PSRLSRASQG LDQTVGPNRV SLWPNNKVHP SST 4294
Keyword

KW-0068--Autocatalytic cleavage
KW-0966--Cell projection
KW-0969--Cilium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0430--Lectin
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001304--C-type_lectin
IPR016186--C-type_lectin-like
IPR016187--C-type_lectin_fold
IPR000483--Cys-rich_flank_reg_C
IPR000203--GPS
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR000372--LRRNT
IPR000434--PC1
IPR022409--PKD/Chitinase_dom
IPR002859--PKD/REJ-like
IPR013122--PKD1_2_channel
IPR000601--PKD_dom
IPR001024--PLAT/LH2_dom
IPR006228--Polycystin_cat
IPR014010--REJ_dom
IPR002889--WSC_carb-bd
IPR013994--WSC_carb-bd_subgr
PROSITE

PS50041--C_TYPE_LECTIN_2
PS50221--GPS
PS51450--LRR
PS50093--PKD
PS50095--PLAT
PS51111--REJ
PS51212--WSC
Pfam

PF00059--Lectin_C
PF13855--LRR_8
PF00801--PKD
PF08016--PKD_channel
PF01477--PLAT
PF02010--REJ
PF01822--WSC
Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0016328--C:lateral plasma membrane
GO:0031512--C:motile primary cilium
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0002133--C:polycystin complex
GO:0072372--C:primary cilium
GO:0005262--F:calcium channel activity
GO:0030246--F:carbohydrate binding
GO:0044325--F:ion channel binding
GO:0019904--F:protein domain specific binding
GO:0019901--F:protein kinase binding
GO:0001568--P:blood vessel development
GO:0048754--P:branching morphogenesis of an epithelial tube
GO:0070588--P:calcium ion transmembrane transport
GO:0006816--P:calcium ion transport
GO:0001502--P:cartilage condensation
GO:0007050--P:cell cycle arrest
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0050982--P:detection of mechanical stimulus
GO:0048565--P:digestive tract development
GO:0001892--P:embryonic placenta development
GO:0030010--P:establishment of cell polarity
GO:0048806--P:genitalia development
GO:0007507--P:heart development
GO:0001701--P:in utero embryonic development
GO:0007259--P:JAK-STAT cascade
GO:0001822--P:kidney development
GO:0001889--P:liver development
GO:0060428--P:lung epithelium development
GO:0036303--P:lymph vessel morphogenesis
GO:0072177--P:mesonephric duct development
GO:0072218--P:metanephric ascending thin limb development
GO:0072205--P:metanephric collecting duct development
GO:0072287--P:metanephric distal tubule morphogenesis
GO:0072237--P:metanephric proximal tubule development
GO:0021915--P:neural tube development
GO:0006807--P:nitrogen compound metabolic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:0060674--P:placenta blood vessel development
GO:0031659--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0032092--P:positive regulation of protein binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006611--P:protein export from nucleus
GO:0030155--P:regulation of cell adhesion
GO:0060236--P:regulation of mitotic spindle organization
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0072001--P:renal system development
GO:0034405--P:response to fluid shear stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0043588--P:skin development
GO:0021510--P:spinal cord development