| Tag |
Content |
| dbPAF ID |
dbPAF-0000380 |
| Uniprot Accession |
O08849; RGS2_MOUSE; Q544S7; Q91WX1; Q9JL24;
|
| Genbank Protein ID |
NP_033087.2;
|
| Genbank Nucleotide ID |
NM_009061.4;
|
| Protein Name |
Regulator of G-protein signaling 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
Rgs2 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.Functional Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 179 | TAQKRVYSLMENNSY | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ NSSAPGKPKT 60
GKKSKQQTFI KPSPEEAQLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK 120
KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKSLIAQ NIQEATSGCF TTAQKRVYSL 180
MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
212Fasta Sequence
>O08849|Rgs2|Mus musculus(Mouse)
MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSAPGKPKTGKKSKQQTFIKPSPEEAQLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKSLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
|
| Keyword |
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0734--Signal transduction inhibitor
KW-0810--Translation regulation
|
| Interpro |
IPR016137--RGS
IPR024066--RGS_subdom1
|
| PROSITE |
PS50132--RGS
|
| Pfam |
PF00615--RGS
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0043005--C:neuron projection
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0050873--P:brown fat cell differentiation
GO:0007049--P:cell cycle
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0010614--P:negative regulation of cardiac muscle hypertrophy
GO:0045744--P:negative regulation of G-protein coupled receptor protein signaling pathway
GO:0043407--P:negative regulation of MAP kinase activity
GO:0010519--P:negative regulation of phospholipase activity
GO:0060452--P:positive regulation of cardiac muscle contraction
GO:0031116--P:positive regulation of microtubule polymerization
GO:0071877--P:regulation of adrenergic receptor signaling pathway
GO:0006417--P:regulation of translation
GO:0055119--P:relaxation of cardiac muscle
GO:0060087--P:relaxation of vascular smooth muscle
GO:0007283--P:spermatogenesis
|
