dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000377
Uniprot Accession O08839; BIN1_RAT;
Genbank Protein ID NP_446411.1;
Genbank Nucleotide ID NM_053959.1;
Protein Name Myc box-dependent-interacting protein 1
Protein Synonyms/Alias Amphiphysin II;Amphiphysin-like protein;Bridging integrator 1;
Gene Name Bin1
Gene Synonyms/Alias Amph2;Amphl;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
159SARHHYESLQTAKKKdbPTM 3.0;PhosphoSitePlus;curated19054758; 16381945; 23193290; 22135298; 22817900; 23984901
286FTVKAQPSDSAPEKGcurated24769528
288VKAQPSDSAPEKGNKcurated24769528
296APEKGNKSPSPPPDGPhosphoSitePlus;curated22135298; 22817900; 21630457; 22276854; 25458152; 23984901;
298EKGNKSPSPPPDGSPPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 22817900; 21630457; 22276854;
304PSPPPDGSPAATPEIPhosphoSitePlus;UniProt;curated22135298; 22673903; 22817900; 21630457; 22276854; 24769528;
308PDGSPAATPEIRVNHPhosphoSitePlus;UniProt;curated22135298; 22673903; 24769528
321NHEPEPASGASPGATcurated23712012; 21630457
324PEPASGASPGATIPKdbPTM 3.0;PhosphoSitePlus;UniProt;curated19054758; 16381945; 23193290; 22135298; 22673903; 25532521;
328SGASPGATIPKSPSQcurated23712012; 21630457
332PGATIPKSPSQLRKGcurated23712012; 21630457; 23984901
334ATIPKSPSQLRKGPPcurated21630457
349VPPPPKHTPSKEMKQdbPTM 3.0;PhosphoSitePlus19054758; 16381945; 23193290; 22135298
494AVVVETFSATVNGAVcurated23712012
Sequence
(Fasta)		MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 60
LQKDLRTYLA SVKAMHEASK KLSECLQEVY EPEWPGRDEA NKIAENNDLL WMDYHQKLVD 120
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK 180
AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN 240
TFQSIAGLEE NFHKEMSKLN QNLNDVLVSL EKQHGSNTFT VKAQPSDSAP EKGNKSPSPP 300
PDGSPAATPE IRVNHEPEPA SGASPGATIP KSPSQLRKGP PVPPPPKHTP SKEMKQEQIL 360
SLFDDAFVPE ISVTTPSQFE APGPFSEQAS LLDLDFEPLP PVASPVKAPT PSGQSIPWDL 420
WEPTESQAGV LPSGEPSSAE GSFAVAWPSQ TAEPGPAQPA EASEVVGGTQ EPGETAASEA 480
TSSSLPAVVV ETFSATVNGA VEGSTTTGRL DLPPGFMFKV QAQHDYTATD TDELQLKAGD 540
VVLVIPFQNP EEQDEGWLMG VKESDWNQHK ELEKCRGVFP ENFTERVQ 589
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0043--Tumor suppressor
Interpro

IPR027267--AH/BAR-dom
IPR003005--Amphiphysin
IPR003023--Amphiphysin_2
IPR004148--BAR_dom
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PF14604--SH3_9
Gene Ontology

GO:0030424--C:axon
GO:0043194--C:axon initial segment
GO:0043679--C:axon terminus
GO:0044300--C:cerebellar mossy fiber
GO:0031674--C:I band
GO:0060987--C:lipid tube
GO:0005874--C:microtubule
GO:0033268--C:node of Ranvier
GO:0005634--C:nucleus
GO:0008021--C:synaptic vesicle
GO:0030315--C:T-tubule
GO:0043196--C:varicosity
GO:0030018--C:Z disc
GO:0051020--F:GTPase binding
GO:0032403--F:protein complex binding
GO:0046982--F:protein heterodimerization activity
GO:0006897--P:endocytosis
GO:0060988--P:lipid tube assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0045807--P:positive regulation of endocytosis
GO:0043547--P:positive regulation of GTPase activity
GO:0071156--P:regulation of cell cycle arrest
GO:0045664--P:regulation of neuron differentiation