dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000376
Uniprot Accession O08838; AMPH_RAT;
Genbank Protein ID NP_071553.1;
Genbank Nucleotide ID NM_022217.1;
Protein Name Amphiphysin
Protein Synonyms/Alias
Gene Name Amph
Gene Synonyms/Alias Amph1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
250FSIQGAPSDSGPLRIdbPTM 3.018344231; 16381945; 23193290
252IQGAPSDSGPLRIAKdbPTM 3.018344231; 16381945; 23193290
262LRIAKTPSPPEEASPdbPTM 3.018344231; 16381945; 23193290
268PSPPEEASPLPSPTAdbPTM 3.018344231; 16381945; 23193290
272EEASPLPSPTASPNHdbPTM 3.018344231; 16381945; 23193290
276PLPSPTASPNHTLAPdbPTM 3.018344231; 16381945; 23193290
285NHTLAPASPAPVRPRdbPTM 3.018344231; 16381945; 23193290
293PAPVRPRSPSQTRKGdbPTM 3.018344231; 16381945; 23193290
310VPPLPKVTPTKELQQdbPTM 3.018344231; 16381945; 23193290
496LPAGEGESPEGAKIDdbPTM 3.018344231; 16381945; 23193290; 19054758
514TELASSESPQAAELEdbPTM 3.018344231; 16381945; 23193290; 19054758
539SVVIEPASNHEGEEHdbPTM 3.018344231; 16381945; 23193290
626HDFEAANSDELTLQRdbPTM 3.018344231; 16381945; 23193290
Sequence
(Fasta)		MADIKTGIFA KNVQKRLNRA QEKVLQKLGK ADETKDEQFE EYVQNFKRQE AEGTRLQREL 60
RGYLAAIKGM QEASMKLTES LHEVYEPDWY GREDVKMVGE KCDVLWEDFH QKLVDGSLLT 120
LDTYLGQFPD IKNRIAKRSR KLVDYDSARH HLEALQSSKR KDESRISKAE EEFQKAQKVF 180
EEFNVDLQEE LPSLWSRRVG FYVNTFKNVS SLEAKFHKEI AVLCHKLYEV MTKLGDQHAD 240
KAFSIQGAPS DSGPLRIAKT PSPPEEASPL PSPTASPNHT LAPASPAPVR PRSPSQTRKG 300
PPVPPLPKVT PTKELQQENI INFFEDNFVP EINVTTPSQN EVLEVKKEET LLDLDFDPFK 360
PDVTPAGSAA ATHSPMSQTL PWDLWTTSTD LVQPASGGSF NDFTQPQDTS LFTMQTDQNM 420
AETEQALPTE PQAEEPPTTA AAPTAGLDLG LEMEEPKEEA AIPPGTDAGE TVGTEGSTGE 480
EAEAEKAALP AGEGESPEGA KIDVESTELA SSESPQAAEL EAGAPQEKVI PSVVIEPASN 540
HEGEEHQETT TGTETREATE DVAPQGPAGE KQELATEPTP LDSQAATPAP AGAVDASLSA 600
GDAAQELPPG FLYKVETLHD FEAANSDELT LQRGDVVLVV PSDSEADQDA GWLVGVKESD 660
WLQYRDLATY KGLFPENFTR HLE 684
Keyword

KW-0002--3D-structure
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
Interpro

IPR027267--AH/BAR-dom
IPR003005--Amphiphysin
IPR003017--Amphiphysin_1
IPR004148--BAR_dom
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
Gene Ontology

GO:0043679--C:axon terminus
GO:0030054--C:cell junction
GO:0005856--C:cytoskeleton
GO:0030672--C:synaptic vesicle membrane
GO:0043195--C:terminal bouton
GO:0008022--F:protein C-terminus binding
GO:0032403--F:protein complex binding
GO:0046982--F:protein heterodimerization activity
GO:0045807--P:positive regulation of endocytosis
GO:0043547--P:positive regulation of GTPase activity