| Tag |
Content |
| dbPAF ID |
dbPAF-0000375 |
| Uniprot Accession |
O08837; CDC5L_RAT;
|
| Genbank Protein ID |
NP_445979.1;
|
| Genbank Nucleotide ID |
NM_053527.1;
|
| Protein Name |
Cell division cycle 5-like protein |
| Protein Synonyms/Alias |
Cdc5-like protein;Pombe Cdc5-related protein; |
| Gene Name |
Cdc5l |
| Gene Synonyms/Alias |
Pcdc5rp; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).Functional Description
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MPRIMIKGGV WRNTEDEILK AAVMKYGKNQ WSRIASLLHR KSAKQCKARW YEWLDPSIKK 60
TEWSREEEEK LLHLAKLMPT QWRTIAPIIG RTAAQCLEHY EFLLDKTAQR DNEEETTDDP 120
RKLKPGEIDP NPETKPARPD PIDMDEDELE MLSEARARLA NTQGKKAKRK AREKQLEEAR 180
RLAALQKRRE LRAAGIEIQK KRKKKRGVDY NAEIPFEKKP ALGFYDTSEE NYQALDADFR 240
KLRQQDLDGE LRSEKEGRDR KKDKQHLKRK KESDLPSAIL QTSGVSEFTK KRSKLVLPAP 300
QISDAELQEV VKVGQASEVA RQTAEESGIT NSASSTLLSE YNVTNNSIAL RTPRTPASQD 360
RILQEAQNLM ALTNVDTPLK GGLNTPLHES DFSGVTPQRQ VVQTPNTVLS TPFRTPSNGA 420
EGLTPRSGTT PKPVTNATPG RTPLRDKLNI NPEDGMADYS DPSYVKQMER ESREHLRLGL 480
LGLPAPKNDF EIVLPENAEK ELEEREMDDT YIEDAADVDA RKQAIRDAER VKEMKRMHKA 540
VQKDLPRPSE VNETILRPLN VEPPLTDLQK SEELIKKEMI TMLHYDLLHH PYEPSGNKKG 600
KNVGFATNNS EHITYLEHSP YEKFSKEDLK KAQDVLVQEM EVVKQGMSHG ELSSEAYNQV 660
WEECYSQVLY LPAQSRYTRA NLASKKDRIE SLEKRLEINR GHMTTEAKRA AKMEKKMKIL 720
LGGYQSRAMG LLKQLNDLWD QIEQAHLELR TFEELKKHED SAIPRRLECL KEDVQRQQER 780
EKELQQRYAD LLMEKETLQA KF
803Fasta Sequence
>O08837|Cdc5l|Rattus norvegicus(Rat)
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREMDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKFSKEDLKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLLKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQQRYADLLMEKETLQAKF
|
| Keyword |
KW-0010--Activator
KW-0131--Cell cycle
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0747--Spliceosome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR021786--Cdc5p/Cef1
IPR009057--Homeodomain-like
IPR017930--Myb_dom
IPR001005--SANT/Myb
|
| PROSITE |
PS51294--HTH_MYB
|
| Pfam |
PF11831--Myb_Cef
|
| Gene Ontology |
GO:0071013--C:catalytic step 2 spliceosome
GO:0005662--C:DNA replication factor A complex
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0032993--C:protein-DNA complex
GO:0000974--C:Prp19 complex
GO:0003677--F:DNA binding
GO:0043522--F:leucine zipper domain binding
GO:0044822--F:poly(A) RNA binding
GO:0019901--F:protein kinase binding
GO:0008157--F:protein phosphatase 1 binding
GO:0001222--F:transcription corepressor binding
GO:0071987--F:WD40-repeat domain binding
GO:0044344--P:cellular response to fibroblast growth factor stimulus
GO:0071352--P:cellular response to interleukin-2
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:1990646--P:cellular response to prolactin
GO:1904568--P:cellular response to wortmannin
GO:0006281--P:DNA repair
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0006397--P:mRNA processing
GO:0006355--P:regulation of transcription, DNA-templated
GO:0008380--P:RNA splicing
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0006351--P:transcription, DNA-templated
|
