dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000374
Uniprot Accession O08816; WASL_RAT;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Neural Wiskott-Aldrich syndrome protein
Protein Synonyms/Alias
Gene Name Wasl
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
196KAKKKRLTKADIGTPdbPTM 3.0;PhosphoSitePlus22250195; 16381945; 23193290; 22135298
202LTKADIGTPSNFQHIdbPTM 3.0;PhosphoSitePlus22250195; 16381945; 23193290; 22135298
239LFDMCGISEAQLKDRdbPTM 3.0;PhosphoSitePlus16257963; 16381945; 23193290; 22135298
248AQLKDRETSKVIYDFdbPTM 3.0;PhosphoSitePlus;SysPTM 2.016641100; 16381945; 23193290; 22135298; 19366988
249QLKDRETSKVIYDFIdbPTM 3.0;PhosphoSitePlus;SysPTM 2.016641100; 16381945; 23193290; 22135298; 19366988
253RETSKVIYDFIEKTGdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated14676198; 16381945; 23193290; 16257963; 16641100; 22135298;
259IYDFIEKTGGVEAVKdbPTM 3.0;PhosphoSitePlus22250195; 16381945; 23193290; 22135298
480KRSKAIHSSDEDEDDPhosphoSitePlus;curated22135298; 21630457
481RSKAIHSSDEDEDDDPhosphoSitePlus;curated22135298; 21630457
Sequence
(Fasta)		MSSGQQPPRR VTNVGSLLLT PQENESLFSF LGKKCVTMSS AVVQLYAADR NCMWSKKCSG 60
VACLVKDNPQ RSYFLRIFDI KDGKLLWEQE LYNNFVYNSP RGYFHTFAGD TCQVALNFAN 120
EEEAKKFRKA VTDLLGRRQR KSEKRRDAPN GPNLPMATVD IKNPEITTNR FYSSQVNNIS 180
HTKEKKKGKA KKKRLTKADI GTPSNFQHIG HVGWDPNTGF DLNNLDPELK NLFDMCGISE 240
AQLKDRETSK VIYDFIEKTG GVEAVKNELR RQAPPPPPPS RGGPPPPPPP PHSSGPPPPP 300
ARGRGAPPPP PSRAPTAAPP PPPPSRPGVV VPPPPPNRMY PPPPPALPSS APSGPPPPPP 360
LSMAGSTAPP PPPPPPPPPG PPPPPGLPSD GDHQVPASSG NKAALLDQIR EGAQLKKVEQ 420
NSRPVSCSGR DALLDQIRQG IQLKSVSDGQ ESTPPTPAPT SGIVGALMEV MQKRSKAIHS 480
SDEDEDDDDE EDFQDDDEWE D 502
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0009--Actin-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000095--CRIB_dom
IPR030214--N-WASP
IPR011993--PH/PTB_dom
IPR011026--WASP_C
IPR000697--WH1/EVH1_dom
IPR003124--WH2_dom
PROSITE

PS50108--CRIB
PS50229--WH1
PS51082--WH2
Pfam

PF00786--PBD
PF00568--WH1
PF02205--WH2
Gene Ontology

GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0007015--P:actin filament organization
GO:0051301--P:cell division
GO:0006900--P:membrane budding
GO:0010324--P:membrane invagination
GO:0097320--P:membrane tubulation
GO:0007067--P:mitotic nuclear division
GO:2000370--P:positive regulation of clathrin-mediated endocytosis
GO:0051491--P:positive regulation of filopodium assembly
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016050--P:vesicle organization
GO:0030050--P:vesicle transport along actin filament