dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000373
Uniprot Accession O08815; SLK_RAT;
Genbank Protein ID NP_062222.2;
Genbank Nucleotide ID NM_019349.2;
Protein Name STE20-like serine/threonine-protein kinase
Protein Synonyms/Alias
Gene Name Slk
Gene Synonyms/Alias Sk2;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Mediates apoptosis and actin stress fiber dissolution.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
2------MSFFNFRKIPhosphoSitePlus22135298
14RKIFKLGSEKKKKQYPhosphoSitePlus;curated22135298; 23984901
181FGVSAKNTRTIQRRDPhosphoSitePlus22135298
183VSAKNTRTIQRRDSFPhosphoSitePlus22135298
189RTIQRRDSFIGTPYWPhosphoSitePlus;curated22135298; 23712012; 21630457
193RRDSFIGTPYWMAPEcurated25532521; 23984901
195DSFIGTPYWMAPEVVcurated25532521
340IPANKRASSDLSIASPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521
341PANKRASSDLSIASScurated25532521
347SSDLSIASSEEDKLSPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
348SDLSIASSEEDKLSQPhosphoSitePlus;UniProt22135298; 22673903
645TDEVDQVSESNSIEEPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457; 23984901; 24945867
647EVDQVSESNSIEELEcurated23984901
649DQVSESNSIEELERLPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457; 24945867
776FLSKTKDSGSVSLQEcurated23984901
778SKTKDSGSVSLQETRPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521
Sequence
(Fasta)		MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60
AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120
LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180
TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240
MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV 300
RELIAEAKAE VTEEVEDGKE EDDDDETESA LPIPANKRAS SDLSIASSEE DKLSQNACIL 360
ESVSERTEHN TSGDKFSNKV LSEKPTPEGP EKTVDVDGPA NDVNLETVAE PNDQAVGFHE 420
NGREKKRPQL ESQPDTEDQQ TVDVNLVGEG NDSNIVILET NTDCLKPEED RNEENQEIIE 480
NKLTQSEEIK DIHIQTMDLV SQETGEKEAD FQAIDNEVGF TKEETQEKLG KDDKTHKVVI 540
SDITSEVGTD EPPGDTQKSA EQSQDAEGGA GEEAPEPAQT LTEKATEGPE AHGAEEEPRS 600
GERVEDKQLE QQSAVCEGEG QVTSTSESTR ATTEEPETDE VDQVSESNSI EELERLGVTG 660
AEEQALGSKG EAATELDLER EENAQELPVK AEPQAPAASQ ASEPPPVLIP SINIHSENTE 720
NKGEMGALPK PETILPPEPE NGKGNDTDSG TGSTVENSSS DLNLSISSFL SKTKDSGSVS 780
LQETRRQKKT LKKTRKFIVD GVEVSVTTSK IVTDSDSKTE ELRFLRRQEL RELRLLQKEE 840
QKAQQQLNGK LQQQREQIFR RFEQEMLSKK RQYDQEIENL EKQQKQTIER LEQEHTNRLR 900
DEAKRIKGEQ EKELSKFQNM LRNRKKEEQE FVQKQQQELD GALKKIIQQQ KAELANIERE 960
CLNNKQQLLR AREAAIWELE ERHLQEKHQL LKQQLKDQYF IQRHQLLKRH EKETEQMQRY 1020
NQRLIEELKN RQTQERARLP KIQRSEAKTR MAMFKKSLRI NSTATPDQDR EKIKQFAAQE 1080
EKRQKNERMA QHQKHESQMR DLQLQCEANV RELHQLQNEK CHLLVEHETQ KLKELDEEHS 1140
QELKEWREKL RPRKKTLEEE FARKLQEQEV FFKMTGESEC LNPSAQSRGC LQTSHPSSTR 1200
APAWAG 1207
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR022165--PKK
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
IPR001943--UVR_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50151--UVR
Pfam

PF00069--Pkinase
PF12474--PKK
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0032147--P:activation of protein kinase activity
GO:0006915--P:apoptotic process
GO:0071356--P:cellular response to tumor necrosis factor
GO:0043065--P:positive regulation of apoptotic process
GO:0033129--P:positive regulation of histone phosphorylation
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0007346--P:regulation of mitotic cell cycle
GO:0023014--P:signal transduction by protein phosphorylation
GO:0031098--P:stress-activated protein kinase signaling cascade