| Tag |
Content |
| dbPAF ID |
dbPAF-0000372 |
| Uniprot Accession |
O08811; ERCC2_MOUSE; Q8C487; Q9DC01;
|
| Genbank Protein ID |
NP_031975.2;
|
| Genbank Nucleotide ID |
NM_007949.4;
|
| Protein Name |
TFIIH basal transcription factor complex helicase XPD subunit |
| Protein Synonyms/Alias |
CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;Xeroderma pigmentosum group D-complementing protein; |
| Gene Name |
Ercc2 |
| Gene Synonyms/Alias |
Xpd; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers (By similarity).Functional Description
ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV SLLALIVAYQ 60
RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE KLPFLGLALS SRKNLCIHPE 120
VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA SLPHCRFYEE FDIHGRQMPL PAGIYNLDDL 180
KALGQRQGWC PYFLARYSIL HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID 240
NVCIDSMSVN LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASVARE 300
TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV QESPPAFLSG 360
LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL ANFATLVSTY AKGFTIIIEP 420
FDDRTPTIAN PVLHFSCMDA SLAIKPVFER FQSVIITSGT LSPLDIYPKI LDFHPVTMAT 480
FTMTLARVCL CPMIIGRGND QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT 540
SYQYMESTVA SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA 600
RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND FLTFDAMRHA 660
AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH LTDSNLNLTV DEGVQVAKYF 720
LRQMAQPFHR EDQLGLSLLS LEQLQSEETL QRIEQIAQQL
761Fasta Sequence
>O08811|Ercc2|Mus musculus(Mouse)
MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLQSEETLQRIEQIAQQL
|
| Keyword |
KW-0004--4Fe-4S
KW-0067--ATP-binding
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
|
| Interpro |
IPR006555--ATP-dep_Helicase_C
IPR010614--DEAD_2
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR013020--DNA_helicase_DNA-repair_Rad3
IPR010643--HBB
IPR014013--Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554--Helicase-like_DEXD_c2
IPR027417--P-loop_NTPase
IPR001945--XPGD_DNA_repair
|
| PROSITE |
PS00690--DEAH_ATP_HELICASE
PS51193--HELICASE_ATP_BIND_2
|
| Pfam |
PF06733--DEAD_2
PF06777--HBB
PF13307--Helicase_C_2
|
| Gene Ontology |
GO:0000439--C:core TFIIH complex
GO:0019907--C:cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0005737--C:cytoplasm
GO:0005675--C:holo TFIIH complex
GO:0071817--C:MMXD complex
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0051539--F:4 iron, 4 sulfur cluster binding
GO:0043139--F:5'-3' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0008022--F:protein C-terminus binding
GO:0047485--F:protein N-terminus binding
GO:0008353--F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007568--P:aging
GO:0006915--P:apoptotic process
GO:0030282--P:bone mineralization
GO:0008283--P:cell proliferation
GO:0032289--P:central nervous system myelin formation
GO:0007059--P:chromosome segregation
GO:0032508--P:DNA duplex unwinding
GO:0006281--P:DNA repair
GO:0040016--P:embryonic cleavage
GO:0043249--P:erythrocyte maturation
GO:0030198--P:extracellular matrix organization
GO:0035315--P:hair cell differentiation
GO:0022405--P:hair cycle process
GO:0048820--P:hair follicle maturation
GO:0060218--P:hematopoietic stem cell differentiation
GO:0001701--P:in utero embryonic development
GO:0035264--P:multicellular organism growth
GO:0006289--P:nucleotide-excision repair
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0043388--P:positive regulation of DNA binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006468--P:protein phosphorylation
GO:1901990--P:regulation of mitotic cell cycle phase transition
GO:0001666--P:response to hypoxia
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0043588--P:skin development
GO:0021510--P:spinal cord development
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0009650--P:UV protection
|
