dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000371
Uniprot Accession O08810; U5S1_MOUSE;
Genbank Protein ID NP_001103465.1; NP_035561.1;
Genbank Nucleotide ID NM_001109995.1; NM_011431.3;
Protein Name 116 kDa U5 small nuclear ribonucleoprotein component
Protein Synonyms/Alias Elongation factor Tu GTP-binding domain-containing protein 2;U5 snRNP-specific protein, 116 kDa;U5-116 kDa;
Gene Name Eftud2
Gene Synonyms/Alias Snrp116;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
3-----MDTDLYDEFGPhosphoSitePlus22135298
6--MDTDLYDEFGNYIPhosphoSitePlus22135298
19YIGPELDSDEDDDELdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated19367708; 19854140; 20415495; 20531401; 16381945; 23193290;
78VYGPEVETIVQEEDTPhosphoSitePlus22135298
85TIVQEEDTQPLTEPIPhosphoSitePlus22135298
253VQERLAVTVCINKIDdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated18779572; 16381945; 23193290; 22135298; 19366988
313VCFSSSQYSICFTLGPhosphoSitePlus22135298
465SDLGEAMSDCDPDGPdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298
647MHDLRKMYSEIDIKVdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated18779572; 16381945; 23193290; 22135298; 19366988
648HDLRKMYSEIDIKVAdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated18779572; 16381945; 23193290; 22135298; 19366988
943TRRRKGLSEDVSISKdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 23984901;
947KGLSEDVSISKFFDDcurated25338131
Sequence
(Fasta)		MDTDLYDEFG NYIGPELDSD EDDDELGRET KDLDEDEDED EDDVGEHEDD HPGMEVVLHE 60
DKKYYPTAEE VYGPEVETIV QEEDTQPLTE PIIKPVKTKK FTLMEQTLPV TVYEMDFLAD 120
LMDNSELIRN VTLCGHLHHG KTCFVDCLIE QTHPEIRKRY DQDLCYTDIL FTEQERGVGI 180
KSTPVTVVLP DTKGKSYLFN IMDTPGHVNF SDEVTAGLRI SDGVVLFIDA AEGVMLNTER 240
LIKHAVQERL AVTVCINKID RLILELKLPP TDAYYKLRHI VDEVNGLISM YSTDENLILS 300
PLLGNVCFSS SQYSICFTLG SFAKIYADTF GDINYQEFAK RLWGDIYFNP KTRKFTKKAP 360
SSSSQRSFVE FILEPLYKIL AQVVGDVDTS LPRTLDELGI HLTKEELKLN IRPLLRLVCK 420
KFFGEFTGFV DMCVQHIPSP KVGAKPKIEH TYTGGVDSDL GEAMSDCDPD GPLMCHTTKM 480
YSTDDGVQFH AFGRVLSGTI HAGQPVKVLG ENYTLEDEED SQICTVGRLW ISVARYHIEV 540
NRVPAGNWVL IEGVDQPIVK TATITEPRGN EEAQIFRPLK FNTTSVIKIA VEPVNPSELP 600
KMLDGLRKVN KSYPSLTTKV EESGEHVILG TGELYLDCVM HDLRKMYSEI DIKVADPVVT 660
FCETVVETSS LKCFAETPNK KNKITMIAEP LEKGLAEDIE NEVVQITWNR KKLGEFFQTK 720
YDWDLLAARS IWAFGPDATG PNILVDDTLP SEVDKALLGS VKDSIVQGFQ WGTREGPLCD 780
ELIRNVKFKI LDAVVAQEPL HRGGGQIIPT ARRVVYSAFL MATPRLMEPY YFVEVQAPAD 840
CVSAVYTVLA RRRGHVTQDA PIPGSPLYTI KAFIPAIDSF GFETDLRTHT QGQAFSLSVF 900
HHWQIVPGDP LDKSIVIRPL EPQPAPHLAR EFMIKTRRRK GLSEDVSISK FFDDPMLLEL 960
AKQDVVLNYP M 972
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0747--Spliceosome
Interpro

IPR009022--EFG_III-V
IPR000640--EFG_V
IPR031950--EFTUD2_N
IPR027417--P-loop_NTPase
IPR020568--Ribosomal_S5_D2-typ_fold
IPR014721--Ribosomal_S5_D2-typ_fold_subgr
IPR005225--Small_GTP-bd_dom
IPR000795--TF_GTP-bd_dom
IPR009000--Transl_B-barrel
IPR005517--Transl_elong_EFG/EF2_IV
IPR004161--Transl_elong_EFTu/EF1A_2
PROSITE

PS51722--G_TR_2
Pfam

PF00679--EFG_C
PF14492--EFG_II
PF03764--EFG_IV
PF16004--EFTUD2
PF03144--GTP_EFTU_D2
Gene Ontology

GO:0015030--C:Cajal body
GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0044822--F:poly(A) RNA binding
GO:0000398--P:mRNA splicing, via spliceosome