| Tag |
Content |
| dbPAF ID |
dbPAF-0000364 |
| Uniprot Accession |
O08792; COE2_MOUSE; Q543D5;
|
| Genbank Protein ID |
NP_001263316.1; NP_034225.1; XP_011243247.1;
|
| Genbank Nucleotide ID |
NM_001276387.1; NM_010095.6; XM_011244945.1;
|
| Protein Name |
Transcription factor COE2 |
| Protein Synonyms/Alias |
Early B-cell factor 2;EBF-2;Metencephalon-mesencephalon-olfactory transcription factor 1;MET-mesencephalon-olfactory TF1;MET-mesencephalon-olfactory transcription factor 1;Olf-1/EBF-like 3;O/E-3;OE-3; |
| Gene Name |
Ebf2 |
| Gene Synonyms/Alias |
Coe2;Mmot1; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.Functional Description
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MFGIQDTLGR GPALKDKSLG AEMDSVRSWV RNVGVVDANV AAQSGVALSR AHFEKQPPSN 60
LRKSNFFHFV LALYDRQGQP VEIERTAFVD FVENDKEQGN EKTNNGTHYK LQLLYSNGVR 120
TEQDLYVRLI DSVTKQPIAY EGQNKNPEMC RVLLTHEVMC SRCCEKKSCG NRNETPSDPV 180
IIDRFFLKFF LKCNQNCLKT AGNPRDMRRF QVVLSTTVNV DGHVLAVSDN MFVHNNSKHG 240
RRARRLDPSE ATPCIKAISP SEGWTTGGAM VIIIGDNFFD GLQVVFGTML VWSELITPHA 300
IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFIYTALNE PTIDYGFQRL QKVIPRHPGD 360
PERLAKEMLL KRAADLVEAL YGTPHNNQDI ILKRAADIAE ALYSVPRNPS QIPALSSSPA 420
HSGMMGINSY GSQLGVSISE STQGNNQGYI RNTSSISPRG YSSSSTPQQS NYSTSSNSMN 480
GYSNVPMANL GVPGSPGFLN GSPTGSPYGI MSSSPTVGSS STSSILPFSS SVFPAVKQKS 540
AFAPVIRPQG SPSPACSSGN GNGFRAMTGL VVPPM
576Fasta Sequence
>O08792|Ebf2|Mus musculus(Mouse)
MFGIQDTLGRGPALKDKSLGAEMDSVRSWVRNVGVVDANVAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEKTNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPSQIPALSSSPAHSGMMGINSYGSQLGVSISESTQGNNQGYIRNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMANLGVPGSPGFLNGSPTGSPYGIMSSSPTVGSSSTSSILPFSSSVFPAVKQKSAFAPVIRPQGSPSPACSSGNGNGFRAMTGLVVPPM
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR011598--bHLH_dom
IPR032200--COE_DBD
IPR032201--COE_HLH
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002909--IPT
IPR003523--Transcription_factor_COE
IPR018350--Transcription_factor_COE_CS
|
| PROSITE |
PS01345--COE
|
| Pfam |
PF16422--COE1_DBD
PF16423--COE1_HLH
PF01833--TIG
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0060612--P:adipose tissue development
GO:0050873--P:brown fat cell differentiation
GO:0001709--P:cell fate determination
GO:0035563--P:positive regulation of chromatin binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006366--P:transcription from RNA polymerase II promoter
|
