| Tag |
Content |
| dbPAF ID |
dbPAF-0000362 |
| Uniprot Accession |
O08789; MNT_MOUSE; P97349; Q6GTJ3;
|
| Genbank Protein ID |
NP_034943.3;
|
| Genbank Nucleotide ID |
NM_010813.3;
|
| Protein Name |
Max-binding protein MNT |
| Protein Synonyms/Alias |
Myc antagonist MNT;Protein ROX; |
| Gene Name |
Mnt |
| Gene Synonyms/Alias |
Rox; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.Functional Description
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEREREREQ EQKRASNLAR LAHALPVEEP 60
RIEAPPLPLS PPAPPPAPPP PLATPAPLTV IPIPVVTNSP QSLPPPPPLP PAAQPLPLAP 120
RQPALVSTPG LSIKEPVTLP TRPQVPTPAP LLPDAKTTVA PTGSPKPLQP LPAPILTIAP 180
HPGVQPQLAP QQPPPPTLGT LKLAPAEEAK SSEQKKRPGG IGTREVHNKL EKNRRAHLKE 240
CFETLKRNIP NVDDKKTSNL SVLRTALRYI QSLKRKEKEY EHEMERLARE KIATQQRLAE 300
LKHELSQWMD VLEIDRVLRQ TGQPEDDQAS TSTASEGEDN VDEEMEGDRA GLGPPKLNHR 360
PQPELLKSAL PTPSTAPAPL PTHPHPHPHP VALSPAHLPV QQQQPPQQKT PLPAPPPPPA 420
TPTQTLVPAP AHLVATAGGG STVIAHTATT HASVIQTVNH VLQGPGGKHI AHIAPSAPSP 480
AVQLAPATPP IGHITVHPAT LNHVAHLGSQ LPLYPQPVAV SQPVAVSHIA HTLSHQQVNG 540
TAGLGPPATV MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A
592Fasta Sequence
>O08789|Mnt|Mus musculus(Mouse)
MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREREQEQKRASNLARLAHALPVEEPRIEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQSLPPPPPLPPAAQPLPLAPRQPALVSTPGLSIKEPVTLPTRPQVPTPAPLLPDAKTTVAPTGSPKPLQPLPAPILTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEAKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNVDEEMEGDRAGLGPPKLNHRPQPELLKSALPTPSTAPAPLPTHPHPHPHPVALSPAHLPVQQQQPPQQKTPLPAPPPPPATPTQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA
|
| Keyword |
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR011598--bHLH_dom
|
| PROSITE |
PS50888--BHLH
|
| Pfam |
PF00010--HLH
|
| Gene Ontology |
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0007569--P:cell aging
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051726--P:regulation of cell cycle
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
