dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000361
Uniprot Accession O08788; DCTN1_MOUSE; E9QLJ1; Q3TZG7;
Genbank Protein ID NP_031861.2;
Genbank Nucleotide ID NM_007835.2;
Protein Name Dynactin subunit 1
Protein Synonyms/Alias 150 kDa dynein-associated polypeptide;DAP-150;DP-150;p150-glued;
Gene Name Dctn1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
103VFEDGADTTSPETPDPhosphoPep 2.019060867
104FEDGADTTSPETPDSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298
105EDGADTTSPETPDSSdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated20415495; 21183079; 16381945; 23193290; 21081558; 19060867;
108ADTTSPETPDSSASKdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 21659604; 16381945; 23193290; 19060867; 22135298;
320MAEERAESLQQEVEAcurated25338131
357GSDGAASSYQLKQLEPhosphoSitePlus22135298
417ERLQEELSQAESTIDcurated25338131
421EELSQAESTIDELKEcurated25338131
541LTNQQEASVERQQQPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.0;curated17203969; 16381945; 23193290; 22135298; 19366988; 22817900
919YDAERPPSKPPPVELdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
1156GALYRKTSQLLEKLNPhosphoSitePlus;curated22135298; 22817900; 25338131
1175HTHVVDITRSSPAAKcurated25338131
1268QRHRLVLTQEQLHQLPhosphoSitePlus22135298
Sequence
(Fasta)		MAQSRRHMSS RTPSGSRMST EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV 60
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE 120
GADAAAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGPSSSLGPS GSASAGELSS 180
SEPSTPAQTP LAAPIIPTPA LTSPGAAPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRSE 240
DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT 300
ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL 360
KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE 420
STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE 480
TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA 540
SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG 600
GDHDCVLVLL LMPRLICKAE LIRKQAQEKF DLSENCSERP GLRGAAGEQL SFAAGLVYSL 660
SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL 720
TKAIKYYQHL YSIHLAEQPE DSTMQLADHI KFTQSALDCM GVEVGRLRAF LQGGQEATDI 780
ALLLRDLETS CSDTRQFCKK IRRRMPGTDA PGIPAALAFG SQVSDTLLDC RKHLTWVVAV 840
LQEVAAAAAQ LIAPLAENEG LPVAALEELA FKASEQIYGS PSSSPYECLR QSCTILISTM 900
NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK 960
IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLDE TQTLLRKKEK DFEETMDALQ 1020
ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEPQR GGAPGQAPGA 1080
LPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILRGAQMK ASLAALPPLH VAKLSLPPHE 1140
GPGGNLVAGA LYRKTSQLLE KLNQLSTHTH VVDITRSSPA AKSPSAQLME QVAQLKSLSD 1200
TIEKLKDEVL KETVTQRPGA TVPTDFATFP SSAFLRAKEE QQDDTVYMGK VTFSCAAGLG 1260
QRHRLVLTQE QLHQLHSRLI S 1282
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0243--Dynein
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR000938--CAP-Gly_domain
IPR027663--DCTN1
IPR022157--Dynactin
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
Pfam

PF01302--CAP_GLY
PF12455--Dynactin
Gene Ontology

GO:0031252--C:cell leading edge
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0030286--C:dynein complex
GO:0000776--C:kinetochore
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0043234--C:protein complex
GO:0030904--C:retromer complex
GO:0000922--C:spindle pole
GO:0003774--F:motor activity
GO:0031122--P:cytoplasmic microtubule organization
GO:0032402--P:melanosome transport
GO:0090316--P:positive regulation of intracellular protein transport
GO:0042147--P:retrograde transport, endosome to Golgi