dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000360
Uniprot Accession O08786; CCKAR_MOUSE; Q8VCC7; Q9DBV6;
Genbank Protein ID NP_033957.1;
Genbank Nucleotide ID NM_009827.2;
Protein Name Cholecystokinin receptor type A
Protein Synonyms/Alias
Gene Name Cckar
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
256SAKEKRLSSGGGGGGdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
265GGGGGGGSSSSRYEDPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
266GGGGGGSSSSRYEDSdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
267GGGGGSSSSRYEDSDPhosphoPep 2.019060867
268GGGGSSSSRYEDSDGPhosphoPep 2.019060867
293KLELQQLSTSSSGGRdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
295ELQQLSTSSSGGRINPhosphoPep 2.019060867
296LQQLSTSSSGGRINRdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
297QQLSTSSSGGRINRIPhosphoPep 2.019060867
420DGRTIRASLSRYSYSPhosphoPep 2.0;curated19060867; 21183079
Sequence
(Fasta)		MDVVDSLLMN GSNITPPCEL GLENETLFCL DQPQPSKEWQ SAVQILLYSF IFLLSVLGNT 60
LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI PNLLKDFIFG SAVCKTTTYF 120
MGTSVSVSTF NLVAISLERY GAICRPLQSR VWQTKSHALK VIAATWCLSF TIMTPYPIYS 180
NLVPFTKNNN QTANMCRFLL PSDAMQQSWQ TFLLLILFLI PGVVMVVAYG LISLELYQGI 240
KFDASQKKSA KEKRLSSGGG GGGGSSSSRY EDSDGCYLQK SRPPRKLELQ QLSTSSSGGR 300
INRIRSSGSA ANLIAKKRVI RMLIVIVVLF FLCWMPIFSA NAWRAYDTVS AEKHLSGTPI 360
SFILLLSYTS SCVNPIIYCF MNKRFRLGFM ATFPCCPNPG PTGVRGEVGE EEDGRTIRAS 420
LSRYSYSHMS TSAPPH 437
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR009126--Cholcskin_rcpt
IPR000596--Cholcy_rcpt_A
IPR015276--CholecystokininA_recpt_N
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
PROSITE

PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
Pfam

PF00001--7tm_1
PF09193--CholecysA-Rec_N
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005768--C:endosome
GO:0005887--C:integral component of plasma membrane
GO:0005764--C:lysosome
GO:0043195--C:terminal bouton
GO:0004951--F:cholecystokinin receptor activity
GO:0042277--F:peptide binding
GO:0031532--P:actin cytoskeleton reorganization
GO:0007409--P:axonogenesis
GO:0032870--P:cellular response to hormone stimulus
GO:0038188--P:cholecystokinin signaling pathway
GO:0007586--P:digestion
GO:0007631--P:feeding behavior
GO:0030900--P:forebrain development
GO:0001696--P:gastric acid secretion
GO:0030073--P:insulin secretion
GO:0001764--P:neuron migration
GO:0031100--P:organ regeneration
GO:0031016--P:pancreas development
GO:0030157--P:pancreatic juice secretion
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0090274--P:positive regulation of somatostatin secretion
GO:0002023--P:reduction of food intake in response to dietary excess
GO:0051924--P:regulation of calcium ion transport
GO:0046883--P:regulation of hormone secretion
GO:0043266--P:regulation of potassium ion transport
GO:0051384--P:response to glucocorticoid
GO:0009408--P:response to heat
GO:0032496--P:response to lipopolysaccharide
GO:0007584--P:response to nutrient
GO:1901652--P:response to peptide
GO:0009314--P:response to radiation
GO:0042594--P:response to starvation
GO:0001659--P:temperature homeostasis