dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000358
Uniprot Accession O08784; TCOF_MOUSE; O08857;
Genbank Protein ID NP_035682.1;
Genbank Nucleotide ID NM_011552.3;
Protein Name Treacle protein
Protein Synonyms/Alias Treacher Collins syndrome protein homolog;
Gene Name Tcof1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex. May participate in certain stages of ribosome biogenesis.
Phosphorylation Sites
dbPAF PTMs: 128 (View all)
PositionPeptidesSourceReferences ( PMIDs )
83SRVSDPVSSSESSDQdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated17622165; 16381945; 23193290; 19367708; 19854140; 21183079;
84RVSDPVSSSESSDQEdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated17622165; 16381945; 23193290; 19367708; 19854140; 21659604;
85VSDPVSSSESSDQEKdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated17622165; 16381945; 23193290; 19367708; 19854140; 21183079;
87DPVSSSESSDQEKEEdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated17622165; 16381945; 23193290; 19367708; 19854140; 21659604;
88PVSSSESSDQEKEEEdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated17622165; 16381945; 23193290; 19367708; 19854140; 21183079;
104ATERAKATPRPTPVNdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 25266776
108AKATPRPTPVNSATAcurated25266776
112PRPTPVNSATAALPScurated25338131
151KTVVHLLSGKSPKKSdbPTM 3.0;PhosphoSitePlus;curated21659605; 16381945; 23193290; 22135298; 25266776
154VHLLSGKSPKKSAEPdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19737024; 19854140; 21183079; 21659604; 21659605; 16381945;
158SGKSPKKSAEPLANTdbPTM 3.0;PhosphoSitePlus;curated21183079; 21659605; 16381945; 23193290; 22135298
165SAEPLANTVLASETEdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 21659605; 16381945; 23193290; 21081558; 19060867;
169LANTVLASETEEEGNdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 19131326; 16381945; 23193290; 19367708; 19737024;
171NTVLASETEEEGNAQdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15345747; 17242355; 19131326; 16381945; 23193290; 19367708;
195TVSAGQGSSSSEDSScurated25338131
214ETDVEVKSPAKPAQAdbPTM 3.0;PhosphoSitePlus19854140; 16381945; 23193290; 22135298
248KLGNVAPTPAKPARAcurated25266776
275AAAAAEESESSEEDScurated25338131
284SSEEDSDSEDEAPAGPhosphoSitePlus;curated22135298; 25338131
309GPHVRADSVSAKGIScurated25266776; 25338131
Sequence
(Fasta)
MAEARKRREL LPLIYHHLLQ AGYVRAAREV KEQSGQKSFL TQPVTLLDIY THWQQTSELG 60
QKQKAEDDET LQAKKSRVSD PVSSSESSDQ EKEEEAATER AKATPRPTPV NSATAALPSK 120
VKEKGKTKTA NKTVNSVSHP GSGKTVVHLL SGKSPKKSAE PLANTVLASE TEEEGNAQAL 180
GPTAKSGTVS AGQGSSSSED SSISSDETDV EVKSPAKPAQ AKASAAPAKD PPARTAPGPT 240
KLGNVAPTPA KPARAAAAAA AAAVAAAAAA AAEESESSEE DSDSEDEAPA GLPSQVKASG 300
KGPHVRADSV SAKGISGKGP ILATPGKTGP AATQAKAERP EKDSETSSED DSDSEDEMPV 360
TVNTPQARTS GKSPRARGTS APAKESSQKG APAVTPGKAR PVAAQAGKPE AKSSEESESD 420
SGETPAAATL TTSPAKVKPL GKSSQVRPVS TVTPGSSGKG ANLPCPGKVG SAALRVQMVK 480
KEDVSESSSA ELDSDGPGSP AKAKASLALP QKVRPVATQV KTDRGKGHSG SSEESSDSEE 540
EAAPAASAAQ AKPALEKQMK ASSRKGTPAS ATGASTSSHC KAGAVTSSAS LSSPALAKGT 600
QRSDVDSSSE SESEGAAPST PRVQGKSGGK GLQGKAALGQ GVAPVHTQKT GPSVKAMAQE 660
DSESLEEDSS SEEEDETPAQ ATPLGRLPQA KANPPPTKTP PASASGKAVA APTKGKPPVP 720
NSTVSARGQR SVPAAGKAGA PATQAQKGPV AGTGEDSESS SKEESDSEEE TPAQIKPVGK 780
TSQVRAASAP AKESPKKGAH PGTPGKTGSS ATQAQPGKTE DSDSSSEESD SDTEMPSAQA 840
IKSPPVSVNR NSSPAVPAPT PEGVQAVNTT KKASGTTAQS SSSESEDGDE DLIPATQPST 900
YALRTSVTTP AALSRAASQP SKSEQSSRMP KGKKAKAAAS AQTSSAVETL PMMPPQSAPI 960
QPKATNKLGK SKLPEKQQLA PGYPKAPRSS EDSSDTSSED EEDAKRPQMP KSAHRLDPDP 1020
SQKETVVEET PTESSEDEMV APSQSLLSGY MTPGLTVANS QASKATPRPD SNSLASSAPA 1080
TKDNPDGKQK SKSQHAADTA LPKTGRKEAS SGSTPQKPKK LKKSTSSSPA PTQTLPNSIT 1140
QRLLEQAWPL SEAQVQASVV KVLTELLEQE RLKATEAIKE SGKKSQKRKL SGDLEAGAPK 1200
NKKKKEQPVP RASAVSPEKA PMTSKAKSKL DKGSAGGKGK GSPGPQGAKE KPDGELLGIK 1260
LESGEQSDPK SKSKKKKSLK KKKDKEKKEK KKGKKSLAKD SASPIQKKKK KKKKSAEPAV 1320
1321
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR006594--LisH
IPR003993--TCS_treacle
IPR017859--Treacle-like_TCS

PROSITE

PS50896--LISH

Pfam

PF03546--Treacle

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0044822--F:poly(A) RNA binding
GO:0042790--P:transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:0006810--P:transport