dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000357 |
| Uniprot Accession | O08775; VGFR2_RAT; |
| Genbank Protein ID | NP_037194.1; |
| Genbank Nucleotide ID | NM_013062.1; |
| Protein Name | Vascular endothelial growth factor receptor 2 |
| Protein Synonyms/Alias | |
| Gene Name | Kdr |
| Gene Synonyms/Alias | Flk1; |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 7 |
| Sequence (Fasta) | MESRALLAVA LWFCVETRAA SVGLPGDSLH PPKLSTQKDI LTILANTTLQ ITCRGQRDLD 60 WLWPNTPRDS EERVLVTECG DSIFCKTLTV PRVVGNDTGA YKCFYRDTDV SSIVYVYVQD 120 HRSPFIASVS DEHGIVYITE NKNKTVVIPC RGSISNLNVS LCARYPEKRF VPDGNRISWD 180 SEKGFTIPSY MISYAGMVFC EAKINDETYQ SIMYIVLVVG YRIYDVVLSP PHEIELSAGE 240 KLVLNCTART ELNVGLDFSW QFPSSKHQHK KIVNRDVKSL PGTVAKMFLS TLTIDSVTKS 300 DQGEYTCTAY SGLMTKKNKT FVRVHTKPFI AFGSGMKSLV EATVGSQVRI PVKYLSYPAP 360 DIKWYRNGRP IESNYTMIVG DELTIMEVSE RDAGNYTVIL TNPISMEKQS HMVSLVVNVP 420 PQIGEKALIS PMDSYQYGTM QTLTCTVYAN PPLHHIQWYW QLEEACSYRP SQTNPYTCKE 480 WRHVKDFQGG NKIEVTKNQY ALIEGKNKTV STLVIQAAYV SALYKCEAIN KAGRGERVIS 540 FHVIRGPEIT VQPATQPTER ESMSLLCTAD RNTFENLTWY KLGSQATSVH MGESLTPVCK 600 NLDALWKLNG TVFSNSTNDI LIVAFQNASL QDQGNYVCSA QDKKTKKRHC LVKQLVILER 660 MAPMITGNLE NQTTTIGETI EVVCPTSGNP TPLITWFKDN ETLVEDSGIV LKDGNRNLTI 720 RRVRKEDGGL YTCQACNVLG CARAETLFII EGVQEKTNLE VIILVGTAVI AMFFWLLLVI 780 LVRTVKRANE GELKTGYLSI VMDPDELPLD ERCERLPYDA SKWEFPRDRL KLGKPLGRGA 840 FGQVIEADAF GIDKTATCKT VAVKMLKEGA THSEHRALMS ELKILIHIGH HLNVVNLLGA 900 CTKPGGPLMV IVEFCKFGNL STYLRGKRNE FVPYKSKGAR FRSGKDYVGE LSVDLKRRLD 960 SITSSQSSAS SGFVEEKSLS DVEEEEASEE LYKDFLTLEH LICYSFQVAK GMEFLASRKC 1020 IHRDLAARNI LLSEKNVVKI CDFGLARDIY KDPDYVRKGD PRLPLKWMAP ETIFDRIYTI 1080 QSGVWSFGVL LWEIFSLGAS PYPGVKIDEK FCRRLKEGTR MRAPDYTTPE MYQTMLDCWH 1140 EDPNQRPAFS ELVEHLGNLL QANAQQDGKD YIVLPMSETL SMEEDSGLSL PTSPVSCMEE 1200 EEVCDPKFHY DNTAGISHYL QNSKRKSRPV SVKTFEDIPL EEPEVKVIPD DSQTDSGMVL 1260 ASEELKTLED RNKLSPSFGG MMPSKSRESV ASEGSNQTSG YQSGYHSDDT DTTVYSSDEA 1320 GLLKLVDVAG HVDSGTTLRS SPV 1344 |
| Keyword | KW-0037--Angiogenesis |
| Interpro | IPR007110--Ig-like_dom |
| PROSITE | PS50835--IG_LIKE |
| Pfam | |
| Gene Ontology | GO:0030054--C:cell junction |