| Tag |
Content |
| dbPAF ID |
dbPAF-0000356 |
| Uniprot Accession |
O08774; RGS12_RAT; O88383;
|
| Genbank Protein ID |
NP_062212.1;
|
| Genbank Nucleotide ID |
NM_019339.1;
|
| Protein Name |
Regulator of G-protein signaling 12 |
| Protein Synonyms/Alias |
|
| Gene Name |
Rgs12 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.Functional Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MYRAGEPGKR QSGPAPPRVR SVEVARGRAG YGFTLSGQAP CVLSCVMRGS PADFVGLRAG 60
DQILAINEIN VKKASHEDVV KLIGKCSGVL RMVISEGSSH VEPSSSDEEG GLCEGKGWLR 120
PKLDSKALGI NRAERVVEEV QSGGIFNMIF ESPSLCASGS EPLKLKQRSL SESAALRLDV 180
GQDSLCTPHP SMLSKEEISK VINDDSVFTV GLDNHDDFGL DASILNVAMV VGYLGSIELP 240
STSSNLEHDS LQAIRGCMRR LRAEQKIHSL VTMKVMHDCV QLVTDRAGVV AEYPAEKLAF 300
SAVCPDDRRF FGLVTMQTND DGCLAQEDEG ALRTSCHVFM VDPDLFHHKI HQGIARRFGF 360
ACTADPDTSG CLEFPASSLP VLQFISVLYR DMGELIEGVR ARAFLDGDAD AHQNNSTSSN 420
SDSGIGNFNQ EEKSNRVLVV DLGGGSSRHG QGSSPGWESV SGRGSQPWSA PWNGTFCHDS 480
EAGSPLETSP NTDRFWDLTK HSGPVFHMEV PPATLRSSIP PSKRGATGSS CGFNQRWLPV 540
HVLQEWQCGH ASDQESYTDS TDGWSSVNCG TLPPPMSKIP ADRYRVEGSF AQAPLSTQKR 600
DWSRKAFGMQ NLFGPHRNVR KTKEDKKSSK LGRGVALAQT SQRTSARRSF GRSRRFSLTR 660
SLDDLESATV SDGELTGADL KDCISNNSLS SNASLPSVQS CRRLRERRVA SWAVSFERLL 720
QDPVGVRYFS DFLRKEFSEE NILFWQACEC FSHVPAHDKK ELSYRAREIF SKFLCSKATT 780
PVNIDSQAQL ADDILNAPHP DMFKEQQLQI FNLMKFDSYT RFLKSQLYQE CVLAEVEGRT 840
LPDSQQVPSS PASKHSISSD HSNVSTPKKL SGKSKSGRSL NEDVGEEDSE KKRKGAFFSW 900
SRSRSTGRSQ KKKDHGDHAH DALHANGGLC RRESQGSVSS AGSLDLSEAC RTSALERDKA 960
AKHCCVHLPD GTSCVVAVKS GFSIKEILSG LCERHGINGA AVDLFLVGGD KPLVLHQDSS 1020
ILATRDLRLG KRTLFRLDLV PINRSVGLKA KPTKPVTEVL RPVVAKYGLD LGSLLVRLSG 1080
EKEPLDLGAP ISSLDGQRVI LEERDPSRGK VSTEKQKGAP VKQSSAVNSS PRNHSAMGEE 1140
RTLGKSNSIK IRGENGKSAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 1200
RADDQRGLLR KEDLVLPEFL RLPPGSSELA LSSPPPVKGF SKRAVTSHGQ EGAVQTEESY 1260
SDSPATSPAS AQSPCSAYSP GSAHSPGSAH SPGSAHSTPG PPGTAQPGEK PTKPSCISTV 1320
QEGTTQAWRR LSPELEAGGI QTVEEEQVAD LTLMGEGDIS SPNSTLLPPP PLPQDTPGPT 1380
RPGTSRF
1388Fasta Sequence
>O08774|Rgs12|Rattus norvegicus(Rat)
MYRAGEPGKRQSGPAPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAINEINVKKASHEDVVKLIGKCSGVLRMVISEGSSHVEPSSSDEEGGLCEGKGWLRPKLDSKALGINRAERVVEEVQSGGIFNMIFESPSLCASGSEPLKLKQRSLSESAALRLDVGQDSLCTPHPSMLSKEEISKVINDDSVFTVGLDNHDDFGLDASILNVAMVVGYLGSIELPSTSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGCLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFGFACTADPDTSGCLEFPASSLPVLQFISVLYRDMGELIEGVRARAFLDGDADAHQNNSTSSNSDSGIGNFNQEEKSNRVLVVDLGGGSSRHGQGSSPGWESVSGRGSQPWSAPWNGTFCHDSEAGSPLETSPNTDRFWDLTKHSGPVFHMEVPPATLRSSIPPSKRGATGSSCGFNQRWLPVHVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQKRDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSLTRSLDDLESATVSDGELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGRTLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRKGAFFSWSRSRSTGRSQKKKDHGDHAHDALHANGGLCRRESQGSVSSAGSLDLSEACRTSALERDKAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQDSSILATRDLRLGKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKEPLDLGAPISSLDGQRVILEERDPSRGKVSTEKQKGAPVKQSSAVNSSPRNHSAMGEERTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPPGSSELALSSPPPVKGFSKRAVTSHGQEGAVQTEESYSDSPATSPASAQSPCSAYSPGSAHSPGSAHSPGSAHSTPGPPGTAQPGEKPTKPSCISTVQEGTTQAWRRLSPELEAGGIQTVEEEQVADLTLMGEGDISSPNSTLLPPPPLPQDTPGPTRPGTSRF
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0734--Signal transduction inhibitor
KW-0832--Ubl conjugation
|
| Interpro |
IPR003109--GoLoco_motif
IPR001478--PDZ
IPR011993--PH/PTB_dom
IPR006020--PTB/PI_dom
IPR003116--Raf-like_ras-bd
IPR016137--RGS
IPR024066--RGS_subdom1
IPR029071--Ubiquitin-rel_dom
|
| PROSITE |
PS50877--GOLOCO
PS50106--PDZ
PS01179--PID
PS50898--RBD
PS50132--RGS
|
| Pfam |
PF02188--GoLoco
PF00595--PDZ
PF02196--RBD
PF00615--RGS
|
| Gene Ontology |
GO:0097440--C:apical dendrite
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0001965--F:G-protein alpha-subunit binding
GO:0005096--F:GTPase activator activity
GO:0005057--F:receptor signaling protein activity
GO:0045744--P:negative regulation of G-protein coupled receptor protein signaling pathway
GO:0043547--P:positive regulation of GTPase activity
GO:0038032--P:termination of G-protein coupled receptor signaling pathway
|
