dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000354
Uniprot Accession O08769; O08769_RAT;
Genbank Protein ID NP_113950.2; XP_006237601.1;
Genbank Nucleotide ID NM_031762.3; XM_006237539.2;
Protein Name Cyclin dependent kinase inhibitor
Protein Synonyms/Alias
Gene Name Cdkn1b
Gene Synonyms/Alias p27Kip1;rCG_29991;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
10NVRVSNGSPSLERMDPhosphoSitePlus;curated22135298; 23712012; 21630457; 23984901
106CKVPAQESLDVSGSRPhosphoSitePlus22135298
175NRTEENVSDGSPNAGcurated21630457
178EENVSDGSPNAGTVEPhosphoSitePlus;curated22135298; 21630457
Sequence
(Fasta)
MSNVRVSNGS PSLERMDARQ TEHPKPSACR NLFGPVNHEE LTRDLEKHCR DMEEASQRKW 60
NFDFQNHKPL EGRYEWQEVE RGSLPEFYYR PPRPPKSACK VPAQESLDVS GSRQAVPSIG 120
SQANSEDRHL VDQMPDSSDS PAGLAEQCPG MRKRPAAEDS SSQNKRANRT EENVSDGSPN 180
AGTVEQTPKK PGLRRQT 198
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0195--Cyclin
KW-0418--Kinase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR003175--CDI
IPR029843--CDKN1B

PROSITE
Pfam

PF02234--CDI

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0051087--F:chaperone binding
GO:0004861--F:cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0030544--F:Hsp70 protein binding
GO:0016301--F:kinase activity
GO:0032403--F:protein complex binding
GO:0048102--P:autophagic cell death
GO:0008219--P:cell death
GO:0071236--P:cellular response to antibiotic
GO:0071285--P:cellular response to lithium ion
GO:0071407--P:cellular response to organic cyclic compound
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0048839--P:inner ear development
GO:0071850--P:mitotic cell cycle arrest
GO:0043066--P:negative regulation of apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0051271--P:negative regulation of cellular component movement
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0060770--P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007219--P:Notch signaling pathway
GO:0008284--P:positive regulation of cell proliferation
GO:0045737--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0031116--P:positive regulation of microtubule polymerization
GO:0045732--P:positive regulation of protein catabolic process
GO:0006813--P:potassium ion transport
GO:0043200--P:response to amino acid
GO:0046686--P:response to cadmium ion
GO:0042493--P:response to drug
GO:0032355--P:response to estradiol
GO:0009749--P:response to glucose
GO:0001666--P:response to hypoxia
GO:0014070--P:response to organic cyclic compound
GO:0043434--P:response to peptide hormone
GO:0007605--P:sensory perception of sound