dbPAF Protein Information
| Tag | Content | ||||||||||||
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| dbPAF ID | dbPAF-0000350 | ||||||||||||
| Uniprot Accession | O08756; HCD2_MOUSE; | ||||||||||||
| Genbank Protein ID | |||||||||||||
| Genbank Nucleotide ID | |||||||||||||
| Protein Name | 3-hydroxyacyl-CoA dehydrogenase type-2 | ||||||||||||
| Protein Synonyms/Alias | 17-beta-hydroxysteroid dehydrogenase 10;17-beta-HSD 10; | ||||||||||||
| Gene Name | Hsd17b10 | ||||||||||||
| Gene Synonyms/Alias | Erab;Hadh2; | ||||||||||||
| Organism | Mus musculus(Mouse) | ||||||||||||
| NCBI Taxa ID | 10090 | ||||||||||||
| Functional Description (View all) |
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (By similarity). | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MAAAVRSVKG LVAVVTGGAS GPWLATAKRL VGQGATAVLL DVPDSEGESQ AKKLGESCIF 60 APANVTSEKE IQAALTLAKE KFGRIDVAVN CAGIAVAIKT YHQKKNKIHT LEDFQRVINV 120 NLIGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIDGMTL 180 PIARDLAPTG IRVVTIAPGL FATPLLTTLP EKVRNFLASQ VPFPSRLGDP AEYAHLVQTI 240 IENPFLNGEV IRLDGAIRMQ P 262 |
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| Keyword | KW-0007--Acetylation |
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| Interpro | IPR002198--DH_sc/Rdtase_SDR |
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| PROSITE | PS00061--ADH_SHORT |
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| Pfam | PF00106--adh_short |
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| Gene Ontology | GO:0005783--C:endoplasmic reticulum |