dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000349
Uniprot Accession O08750; NFIL3_MOUSE; Q3ULK2; Q497U0;
Genbank Protein ID NP_059069.1; XP_006516938.1; XP_006516939.1; XP_006516940.1; XP_006516941.1; XP_011242681.1;
Genbank Nucleotide ID NM_017373.3; XM_006516875.1; XM_006516876.2; XM_006516877.1; XM_006516878.1; XM_011244379.1;
Protein Name Nuclear factor interleukin-3-regulated protein
Protein Synonyms/Alias E4 promoter-binding protein 4;Embryo implantation-related NFIL3/E4BP4-like transcription factor;
Gene Name Nfil3
Gene Synonyms/Alias E4bp4;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites (By similarity). Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells (By similarity). Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
130KLKFGLISSTAYAQEdbPTM 3.0;PhosphoSitePlus;curated19854140; 16381945; 23193290; 22135298; 22817900
210PAQGGCRSPENKFPVdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated19854140; 16381945; 23193290; 21081558; 22135298; 22817900
250IYQSYMGSSFSTYSHPhosphoSitePlus22135298
251YQSYMGSSFSTYSHSPhosphoSitePlus22135298
285DEGVVGKSSDGEDEQcurated25266776; 21743459; 23984901; 25338131
286EGVVGKSSDGEDEQQdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17242355; 16381945; 23193290; 19060867; 22135298; 19366988;
301VPKGPIHSPVELQRVdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19854140; 20531401; 21659605; 16381945; 23193290; 21081558;
353EGMQKLSSPADAIAKdbPTM 3.0;PhosphoSitePlus;curated19854140; 16381945; 23193290; 22135298; 25266776; 22817900;
Sequence
(Fasta)		MQLRKMQTIK KEPAPLDPTS SSDKMLLLNS ALAEVAEDLA SGEDLLLNEG SMGKNKSSAC 60
RRKREFIPDE KKDAMYWEKR RKNNEAAKRS REKRRLNDLV LENKLIALGE ENATLKAELL 120
SLKLKFGLIS STAYAQEIQK LSNSTAVYFQ DYQTSKAAVS SFVDEHEPAM VAGSCISVIK 180
HSPQSSLSDV SEVSSVEHTQ ESPAQGGCRS PENKFPVIKQ EPVELESFAR EAREERGTYS 240
TSIYQSYMGS SFSTYSHSPP LLQVHGSTSN SPRTSEADEG VVGKSSDGED EQQVPKGPIH 300
SPVELQRVHA TVVKVPEVNP SALPHKLRIK AKAMQVKVEA LDSEFEGMQK LSSPADAIAK 360
RHFDLEKHGT SGMAHSSLPP FSVQVTNIQD WSLKSEHWHH KELSSKTQSS FKTGVVEVKD 420
GGYKVSEAEN LYLKQGIANL SAEVVSLKRF IATQPISASD SR 463
Keyword

KW-0010--Activator
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR004827--bZIP
IPR016743--NFIL3/E4BP4
IPR010533--Vert_IL3-reg_TF
PROSITE

PS50217--BZIP
PS00036--BZIP_BASIC
Pfam

PF07716--bZIP_2
PF06529--Vert_IL3-reg_TF
Gene Ontology

GO:0005634--C:nucleus
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0071353--P:cellular response to interleukin-4
GO:0007623--P:circadian rhythm
GO:0006955--P:immune response
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0010628--P:positive regulation of gene expression
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006366--P:transcription from RNA polymerase II promoter