| Tag |
Content |
| dbPAF ID |
dbPAF-0000348 |
| Uniprot Accession |
O08749; DLDH_MOUSE; Q3TG55; Q3U5W5; Q3UWP7; Q99LD3;
|
| Genbank Protein ID |
NP_031887.2;
|
| Genbank Nucleotide ID |
NM_007861.5;
|
| Protein Name |
Dihydrolipoyl dehydrogenase, mitochondrial |
| Protein Synonyms/Alias |
Dihydrolipoamide dehydrogenase; |
| Gene Name |
Dld |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.Functional Description
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MQSWSRVYRS LAKKGHFNRI SHGLQGVSSV PLRTYADQPI EADVTVIGSG PGGYVAAIKS 60
AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEIPEVRLNL 120
EKMMEQKHSA VKALTGGIAH LFKQNKVVHV NGFGKITGKN QVTATKADGS TQVIDTKNIL 180
VATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKLVVIG AGVIGVELGS VWQRLGADVT 240
AVEFLGHVGG IGIDMEISKN FQRILQRQGF KFKLNTKVTG ATKKSDGKID VSVEAASGGK 300
AEVITCDVLL VCIGRRPFTQ NLGLEELGIE LDPKGRIPVN NRFQTKIPNI YAIGDVVAGP 360
MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEFKIGK 420
FPFAANSRAK TNADTDGMVK ILGHKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI 480
ARVCHAHPTL SEAFREANLA AAFGKPINF
Fasta Sequence
>O08749|Dld|Mus musculus(Mouse)
MQSWSRVYRSLAKKGHFNRISHGLQGVSSVPLRTYADQPIEADVTVIGSGPGGYVAAIKSAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEIPEVRLNLEKMMEQKHSAVKALTGGIAHLFKQNKVVHVNGFGKITGKNQVTATKADGSTQVIDTKNILVATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKLVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGIGIDMEISKNFQRILQRQGFKFKLNTKVTGATKKSDGKIDVSVEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIELDPKGRIPVNNRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEFKIGKFPFAANSRAKTNADTDGMVKILGHKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAAAFGKPINF
|
| Keyword |
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0274--FAD
KW-0285--Flavoprotein
KW-0496--Mitochondrion
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0676--Redox-active center
KW-1185--Reference proteome
KW-0809--Transit peptide
|
| Interpro |
IPR023753--FAD/NAD-binding_dom
IPR016156--FAD/NAD-linked_Rdtase_dimer
IPR006258--Lipoamide_DH
IPR004099--Pyr_nucl-diS_OxRdtase_dimer
IPR012999--Pyr_OxRdtase_I_AS
|
| PROSITE |
PS00076--PYRIDINE_REDOX_1
|
| Pfam |
PF07992--Pyr_redox_2
PF02852--Pyr_redox_dim
|
| Gene Ontology |
GO:0043159--C:acrosomal matrix
GO:0005929--C:cilium
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0043209--C:myelin sheath
GO:0005654--C:nucleoplasm
GO:0045252--C:oxoglutarate dehydrogenase complex
GO:0045254--C:pyruvate dehydrogenase complex
GO:0004148--F:dihydrolipoyl dehydrogenase activity
GO:0050660--F:flavin adenine dinucleotide binding
GO:0043544--F:lipoamide binding
GO:0051287--F:NAD binding
GO:0006103--P:2-oxoglutarate metabolic process
GO:0007568--P:aging
GO:0045454--P:cell redox homeostasis
GO:0051068--P:dihydrolipoamide metabolic process
GO:0007369--P:gastrulation
GO:0009106--P:lipoate metabolic process
GO:0061732--P:mitochondrial acetyl-CoA biosynthetic process from pyruvate
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0006508--P:proteolysis
GO:0042391--P:regulation of membrane potential
GO:0048240--P:sperm capacitation
|
