dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000347
Uniprot Accession O08747; UNC5C_MOUSE; Q8CD16;
Genbank Protein ID NP_033498.1;
Genbank Nucleotide ID NM_009472.4;
Protein Name Netrin receptor UNC5C
Protein Synonyms/Alias Protein unc-5 homolog 3;Protein unc-5 homolog C;Rostral cerebellar malformation protein;
Gene Name Unc5c
Gene Synonyms/Alias Rcm;Unc5h3;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC (PubMed:9126743, PubMed:9389662, PubMed:12451134). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
489YNSSGAVTPQDDLAEPhosphoSitePlus22135298
502AEFSSKLSPQMTQSLdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated20415495; 21183079; 16381945; 23193290; 21081558; 19060867;
526NQSLARQTDPSCTAFPhosphoSitePlus22135298
535PSCTAFGTFNSLGGHPhosphoSitePlus22135298
538TAFGTFNSLGGHLIIPhosphoSitePlus22135298
568QGRVYEMYVTVHRKEdbPTM 3.0;PhosphoSitePlus;UniProt11533026; 16381945; 23193290; 22135298
693IFGPLCCSSLEYSIRdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated20415495; 16381945; 23193290; 21081558; 19060867; 22135298;
694FGPLCCSSLEYSIRVPHOSIDA;PhosphoPep 2.021081558; 19060867
889FATKSSPTGVILDLWPhosphoSitePlus22135298
Sequence
(Fasta)		MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDEFFHELP ETFPSDPPEP 60
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHVVDER VDETSGLIVR 120
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 180
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP AEDRNFYITI DHNLIIKQAR LSDTANYTCV 240
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 300
GQSVQKIACT TLCPVDGRWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 360
NCTDGLCMQA APDSDDVALY VGIVIAVTVC LAITVVVALF VYRKNHRDFE SDIIDSSALN 420
GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK 480
VYNSSGAVTP QDDLAEFSSK LSPQMTQSLL ENEALNLKNQ SLARQTDPSC TAFGTFNSLG 540
GHLIIPNSGV SLLIPAGAIP QGRVYEMYVT VHRKENMRPP MEDSQTLLTP VVSCGPPGAL 600
LTRPVILTLH HCADPSTEDW KIQLKNQAVQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL 660
TENLSTYALV GQSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEVLQLERQ 720
MGGQLLEEPK ALHFKGSIHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHIW SGSQRNLHCT 780
FTLERLSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA STITTVTGPS 840
AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN 900
FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y 932
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0770--Synapse
KW-0771--Synaptosome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003598--Ig_sub2
IPR000884--TSP1_rpt
IPR000906--ZU5_dom
PROSITE

PS50835--IG_LIKE
PS50092--TSP1
PS51145--ZU5
Pfam

PF00531--Death
PF07679--I-set
PF00090--TSP_1
PF00791--ZU5
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005042--F:netrin receptor activity
GO:0033564--P:anterior/posterior axon guidance
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0007420--P:brain development
GO:0038007--P:netrin-activated signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0030334--P:regulation of cell migration