| Tag |
Content |
| dbPAF ID |
dbPAF-0000345 |
| Uniprot Accession |
O08738; CASP6_MOUSE;
|
| Genbank Protein ID |
NP_033941.3;
|
| Genbank Nucleotide ID |
NM_009811.4;
|
| Protein Name |
Caspase-6 |
| Protein Synonyms/Alias |
|
| Gene Name |
Casp6 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity).Functional Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MTETDGFYKS REVFDPAEQY KMDHKRRGVA LIFNHERFFW HLTLPERRGT NADRDNLTRR 60
FSDLGFEVKC FNDLRAEELL LKIHEVSTSS HIDADCFICV FLSHGEGNHV YAYDAKIEIQ 120
TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ HDVPVVPLDM VDHQTDKLDN VTQVDAASVY 180
TLPAGADFLM CYSVAEGYYS HRETVNGSWY IQDLCEMLAR YGSSLEFTEL LTLVNRKVSQ 240
RRVDFCKDPD AIGKKQVPCF ASMLTKKLHF CPKPSK
277Fasta Sequence
>O08738|Casp6|Mus musculus(Mouse)
MTETDGFYKSREVFDPAEQYKMDHKRRGVALIFNHERFFWHLTLPERRGTNADRDNLTRRFSDLGFEVKCFNDLRAEELLLKIHEVSTSSHIDADCFICVFLSHGEGNHVYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPVVPLDMVDHQTDKLDNVTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLARYGSSLEFTELLTLVNRKVSQRRVDFCKDPDAIGKKQVPCFASMLTKKLHFCPKPSK
|
| Keyword |
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0865--Zymogen
|
| Interpro |
IPR029030--Caspase-like_dom
IPR011600--Pept_C14_caspase
IPR001309--Pept_C14_ICE_p20
IPR016129--Pept_C14_ICE_p20_AS
IPR002138--Pept_C14_p10
IPR015917--Pept_C14A_p45_core
|
| PROSITE |
PS01122--CASPASE_CYS
PS01121--CASPASE_HIS
PS50207--CASPASE_P10
PS50208--CASPASE_P20
|
| Pfam |
PF00656--Peptidase_C14
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0097200--F:cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0004175--F:endopeptidase activity
GO:0042802--F:identical protein binding
GO:0006915--P:apoptotic process
GO:0030855--P:epithelial cell differentiation
GO:0097194--P:execution phase of apoptosis
GO:0006508--P:proteolysis
|
