dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000344
Uniprot Accession O08736; CASPC_MOUSE; Q3TT82;
Genbank Protein ID NP_033938.3;
Genbank Nucleotide ID NM_009808.4;
Protein Name Caspase-12
Protein Synonyms/Alias
Gene Name Casp12
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Involved in the activation cascade of caspases responsible for apoptosis execution.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
49LKIGESASFILNKAEcurated25338131
80FAGHIANSQEQLSLQcurated25338131
89EQLSLQFSNDEDDGPcurated25338131
104QKICTPSSPSESKRKPhosphoSitePlus;curated22135298; 23684622; 25338131
408MPTIERVSMTRYFYLPhosphoSitePlus22135298
412ERVSMTRYFYLFPGNPhosphoSitePlus22135298
414VSMTRYFYLFPGN--PhosphoSitePlus22135298
Sequence
(Fasta)		MAARRTHERD PIYKIKGLAK DMLDGVFDDL VEKNVLNGDE LLKIGESASF ILNKAENLVE 60
NFLEKTDMAG KIFAGHIANS QEQLSLQFSN DEDDGPQKIC TPSSPSESKR KVEDDEMEVN 120
AGLAHESHLM LTAPHGLQSS EVQDTLKLCP RDQFCKIKTE RAKEIYPVME KEGRTRLALI 180
ICNKKFDYLF DRDNADTDIL NMQELLENLG YSVVLKENLT AQEMETELMQ FAGRPEHQSS 240
DSTFLVFMSH GILEGICGVK HRNKKPDVLH DDTIFKIFNN SNCRSLRNKP KILIMQACRG 300
RYNGTIWVST NKGIATADTD EERVLSCKWN NSITKAHVET DFIAFKSSTP HNISWKVGKT 360
GSLFISKLID CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ MPTIERVSMT RYFYLFPGN 420
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0865--Zymogen
Interpro

IPR001315--CARD
IPR029030--Caspase-like_dom
IPR011029--DEATH-like_dom
IPR011600--Pept_C14_caspase
IPR001309--Pept_C14_ICE_p20
IPR016129--Pept_C14_ICE_p20_AS
IPR002138--Pept_C14_p10
IPR017350--Pept_C14A_Casp1-type
IPR015917--Pept_C14A_p45_core
PROSITE

PS50209--CARD
PS01122--CASPASE_CYS
PS01121--CASPASE_HIS
PS50207--CASPASE_P10
PS50208--CASPASE_P20
Pfam

PF00619--CARD
PF00656--Peptidase_C14
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0004197--F:cysteine-type endopeptidase activity
GO:0006915--P:apoptotic process
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0042981--P:regulation of apoptotic process
GO:0097264--P:self proteolysis