dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000343
Uniprot Accession O08734; BAK_MOUSE; E9QM21; Q8C264;
Genbank Protein ID NP_031549.2;
Genbank Nucleotide ID NM_007523.2;
Protein Name Bcl-2 homologous antagonist/killer
Protein Synonyms/Alias Apoptosis regulator BAK;
Gene Name Bak1
Gene Synonyms/Alias Bak;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
17PKVGCDESPSPSEQQPhosphoSitePlus;curated22135298; 25266776; 25338131
19VGCDESPSPSEQQVAPhosphoSitePlus;curated22135298; 25266776; 23684622
21CDESPSPSEQQVAQDPhosphoSitePlus;curated22135298; 25266776
Sequence
(Fasta)
MASGQGPGPP KVGCDESPSP SEQQVAQDTE EVFRSYVFYL HQQEQETQGA AAPANPEMDN 60
LPLEPNSILG QVGRQLALIG DDINRRYDTE FQNLLEQLQP TAGNAYELFT KIASSLFKSG 120
ISWGRVVALL GFGYRLALYV YQRGLTGFLG QVTCFLADII LHHYIARWIA QRGGWVAALN 180
FRRDPILTVM VIFGVVLLGQ FVVHRFFRS
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc

Interpro

IPR002475--Bcl2-like
IPR020717--Bcl2_BH1_motif_CS
IPR020726--Bcl2_BH2_motif_CS
IPR020728--Bcl2_BH3_motif_CS
IPR026298--Blc2_fam

PROSITE

PS50062--BCL2_FAMILY
PS01080--BH1
PS01258--BH2
PS01259--BH3

Pfam

PF00452--Bcl-2

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0031307--C:integral component of mitochondrial outer membrane
GO:0005622--C:intracellular
GO:0031966--C:mitochondrial membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0046930--C:pore complex
GO:0042802--F:identical protein binding
GO:0044325--F:ion channel binding
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0097202--P:activation of cysteine-type endopeptidase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568--P:aging
GO:0006915--P:apoptotic process
GO:1902262--P:apoptotic process involved in patterning of blood vessels
GO:0097190--P:apoptotic signaling pathway
GO:0001783--P:B cell apoptotic process
GO:0001782--P:B cell homeostasis
GO:0002352--P:B cell negative selection
GO:0001974--P:blood vessel remodeling
GO:0007420--P:brain development
GO:0008283--P:cell proliferation
GO:0071260--P:cellular response to mechanical stimulus
GO:0034644--P:cellular response to UV
GO:0019835--P:cytolysis
GO:0031018--P:endocrine pancreas development
GO:0010248--P:establishment or maintenance of transmembrane electrochemical gradient
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0044346--P:fibroblast apoptotic process
GO:0048872--P:homeostasis of number of cells
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001776--P:leukocyte homeostasis
GO:0035108--P:limb morphogenesis
GO:0008053--P:mitochondrial fusion
GO:0002262--P:myeloid cell homeostasis
GO:0008285--P:negative regulation of cell proliferation
GO:0032471--P:negative regulation of endoplasmic reticulum calcium ion concentration
GO:0010629--P:negative regulation of gene expression
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:0031100--P:organ regeneration
GO:0043065--P:positive regulation of apoptotic process
GO:0010524--P:positive regulation of calcium ion transport into cytosol
GO:1900103--P:positive regulation of endoplasmic reticulum unfolded protein response
GO:0045862--P:positive regulation of proteolysis
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0048597--P:post-embryonic camera-type eye morphogenesis
GO:0051726--P:regulation of cell cycle
GO:0046902--P:regulation of mitochondrial membrane permeability
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0043497--P:regulation of protein heterodimerization activity
GO:0043496--P:regulation of protein homodimerization activity
GO:0001836--P:release of cytochrome c from mitochondria
GO:0042493--P:response to drug
GO:0045471--P:response to ethanol
GO:0009620--P:response to fungus
GO:0010332--P:response to gamma radiation
GO:0042542--P:response to hydrogen peroxide
GO:0010046--P:response to mycotoxin
GO:0014070--P:response to organic cyclic compound
GO:0010225--P:response to UV-C
GO:0070242--P:thymocyte apoptotic process
GO:0060068--P:vagina development