Tag |
Content |
dbPAF ID |
dbPAF-0000343 |
Uniprot Accession |
O08734; BAK_MOUSE; E9QM21; Q8C264; |
Genbank Protein ID |
NP_031549.2; |
Genbank Nucleotide ID |
NM_007523.2; |
Protein Name |
Bcl-2 homologous antagonist/killer |
Protein Synonyms/Alias |
Apoptosis regulator BAK; |
Gene Name |
Bak1 |
Gene Synonyms/Alias |
Bak; |
Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2.Functional Description
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2.
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Phosphorylation Sites
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dbPAF PTMs: 3 |
Sequence (Fasta) | MASGQGPGPP KVGCDESPSP SEQQVAQDTE EVFRSYVFYL HQQEQETQGA AAPANPEMDN 60 LPLEPNSILG QVGRQLALIG DDINRRYDTE FQNLLEQLQP TAGNAYELFT KIASSLFKSG 120 ISWGRVVALL GFGYRLALYV YQRGLTGFLG QVTCFLADII LHHYIARWIA QRGGWVAALN 180 FRRDPILTVM VIFGVVLLGQ FVVHRFFRS
Fasta Sequence
>O08734|Bak1|Mus musculus(Mouse) MASGQGPGPPKVGCDESPSPSEQQVAQDTEEVFRSYVFYLHQQEQETQGAAAPANPEMDNLPLEPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQPTAGNAYELFTKIASSLFKSGISWGRVVALLGFGYRLALYVYQRGLTGFLGQVTCFLADIILHHYIARWIAQRGGWVAALNFRRDPILTVMVIFGVVLLGQFVVHRFFRS
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Keyword |
KW-0002--3D-structure KW-0007--Acetylation KW-0053--Apoptosis KW-0181--Complete proteome KW-0472--Membrane KW-0479--Metal-binding KW-0496--Mitochondrion KW-1185--Reference proteome KW-0812--Transmembrane KW-1133--Transmembrane helix KW-0862--Zinc
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Interpro |
IPR002475--Bcl2-like IPR020717--Bcl2_BH1_motif_CS IPR020726--Bcl2_BH2_motif_CS IPR020728--Bcl2_BH3_motif_CS IPR026298--Blc2_fam
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PROSITE |
PS50062--BCL2_FAMILY PS01080--BH1 PS01258--BH2 PS01259--BH3
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Pfam |
PF00452--Bcl-2
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Gene Ontology |
GO:0005829--C:cytosol GO:0005783--C:endoplasmic reticulum GO:0031307--C:integral component of mitochondrial outer membrane GO:0005622--C:intracellular GO:0031966--C:mitochondrial membrane GO:0005741--C:mitochondrial outer membrane GO:0005739--C:mitochondrion GO:0046930--C:pore complex GO:0042802--F:identical protein binding GO:0044325--F:ion channel binding GO:0046872--F:metal ion binding GO:0046982--F:protein heterodimerization activity GO:0042803--F:protein homodimerization activity GO:0097202--P:activation of cysteine-type endopeptidase activity GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0007568--P:aging GO:0006915--P:apoptotic process GO:1902262--P:apoptotic process involved in patterning of blood vessels GO:0097190--P:apoptotic signaling pathway GO:0001783--P:B cell apoptotic process GO:0001782--P:B cell homeostasis GO:0002352--P:B cell negative selection GO:0001974--P:blood vessel remodeling GO:0007420--P:brain development GO:0008283--P:cell proliferation GO:0071260--P:cellular response to mechanical stimulus GO:0034644--P:cellular response to UV GO:0019835--P:cytolysis GO:0031018--P:endocrine pancreas development GO:0010248--P:establishment or maintenance of transmembrane electrochemical gradient GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand GO:0044346--P:fibroblast apoptotic process GO:0048872--P:homeostasis of number of cells GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0001776--P:leukocyte homeostasis GO:0035108--P:limb morphogenesis GO:0008053--P:mitochondrial fusion GO:0002262--P:myeloid cell homeostasis GO:0008285--P:negative regulation of cell proliferation GO:0032471--P:negative regulation of endoplasmic reticulum calcium ion concentration GO:0010629--P:negative regulation of gene expression GO:0033137--P:negative regulation of peptidyl-serine phosphorylation GO:0031100--P:organ regeneration GO:0043065--P:positive regulation of apoptotic process GO:0010524--P:positive regulation of calcium ion transport into cytosol GO:1900103--P:positive regulation of endoplasmic reticulum unfolded protein response GO:0045862--P:positive regulation of proteolysis GO:0090200--P:positive regulation of release of cytochrome c from mitochondria GO:0048597--P:post-embryonic camera-type eye morphogenesis GO:0051726--P:regulation of cell cycle GO:0046902--P:regulation of mitochondrial membrane permeability GO:0051881--P:regulation of mitochondrial membrane potential GO:0043497--P:regulation of protein heterodimerization activity GO:0043496--P:regulation of protein homodimerization activity GO:0001836--P:release of cytochrome c from mitochondria GO:0042493--P:response to drug GO:0045471--P:response to ethanol GO:0009620--P:response to fungus GO:0010332--P:response to gamma radiation GO:0042542--P:response to hydrogen peroxide GO:0010046--P:response to mycotoxin GO:0014070--P:response to organic cyclic compound GO:0010225--P:response to UV-C GO:0070242--P:thymocyte apoptotic process GO:0060068--P:vagina development
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