| Tag |
Content |
| dbPAF ID |
dbPAF-0000340 |
| Uniprot Accession |
O08721; UNC5A_RAT;
|
| Genbank Protein ID |
NP_071542.1;
|
| Genbank Nucleotide ID |
NM_022206.1;
|
| Protein Name |
Netrin receptor UNC5A |
| Protein Synonyms/Alias |
Protein unc-5 homolog 1;Protein unc-5 homolog A; |
| Gene Name |
Unc5a |
| Gene Synonyms/Alias |
Unc5h1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Receptor for netrin required for axon guidance (PubMed:9126742, PubMed:10399920). Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1 (PubMed:19755150). Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin (PubMed:10399920). Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion (PubMed:10399920). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206, PubMed:12598531).Functional Description
Receptor for netrin required for axon guidance (PubMed:9126742, PubMed:10399920). Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1 (PubMed:19755150). Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin (PubMed:10399920). Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion (PubMed:10399920). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206, PubMed:12598531). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MAVRPGLWPV LLGIVLAAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP EDVYIVKNKP 60
VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDSSSGLP TMEVRINVSR QQVEKVFGLE 120
EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE 180
VEWLRNEDLV DPSLDPNVYI TREHSLVVRQ ARLADTANYT CVAKNIVARR RSTSAAVIVY 240
VNGGWSTWTE WSVCSASCGR GWQKRSRSCT NPAPLNGGAF CEGQNVQKTA CATLCPVDGS 300
WSSWSKWSAC GLDCTHWRSR ECSDPAPRNG GEECRGADLD TRNCTSDLCL HTASCPEDVA 360
LYIGLVAVAV CLFLLLLALG LIYCRKKEGL DSDVADSSIL TSGFQPVSIK PSKADNPHLL 420
TIQPDLSTTT TTYQGSLCSR QDGPSPKFQL SNGHLLSPLG SGRHTLHHSS PTSEAEDFVS 480
RLSTQNYFRS LPRGTSNMAY GTFNFLGGRL MIPNTGISLL IPPDAIPRGK IYEIYLTLHK 540
PEDVRLPLAG CQTLLSPVVS CGPPGVLLTR PVILAMDHCG EPSPDSWSLR LKKQSCEGSW 600
EDVLHLGEES PSHLYYCQLE AGACYVFTEQ LGRFALVGEA LSVAATKRLR LLLFAPVACT 660
SLEYNIRVYC LHDTHDALKE VVQLEKQLGG QLIQEPRVLH FKDSYHNLRL SIHDVPSSLW 720
KSKLLVSYQE IPFYHIWNGT QQYLHCTFTL ERINASTSDL ACKVWVWQVE GDGQSFNINF 780
NITKDTRFAE LLALESEGGV PALVGPSAFK IPFLIRQKII ASLDPPCSRG ADWRTLAQKL 840
HLDSHLSFFA SKPSPTAMIL NLWEARHFPN GNLGQLAAAV AGLGQPDAGL FTVSEAEC
899Fasta Sequence
>O08721|Unc5a|Rattus norvegicus(Rat)
MAVRPGLWPVLLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDSSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSTSAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTACATLCPVDGSWSSWSKWSACGLDCTHWRSRECSDPAPRNGGEECRGADLDTRNCTSDLCLHTASCPEDVALYIGLVAVAVCLFLLLLALGLIYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCSRQDGPSPKFQLSNGHLLSPLGSGRHTLHHSSPTSEAEDFVSRLSTQNYFRSLPRGTSNMAYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPVVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEESPSHLYYCQLEAGACYVFTEQLGRFALVGEALSVAATKRLRLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQQYLHCTFTLERINASTSDLACKVWVWQVEGDGQSFNINFNITKDTRFAELLALESEGGVPALVGPSAFKIPFLIRQKIIASLDPPCSRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLGQLAAAVAGLGQPDAGLFTVSEAEC
|
| Keyword |
KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003599--Ig_sub
IPR000884--TSP1_rpt
IPR000906--ZU5_dom
|
| PROSITE |
PS50835--IG_LIKE
PS50092--TSP1
PS51145--ZU5
|
| Pfam |
PF00531--Death
PF07679--I-set
PF00090--TSP_1
PF00791--ZU5
|
| Gene Ontology |
GO:0016021--C:integral component of membrane
GO:0031226--C:intrinsic component of plasma membrane
GO:0032589--C:neuron projection membrane
GO:0032809--C:neuronal cell body membrane
GO:0005886--C:plasma membrane
GO:0005042--F:netrin receptor activity
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0038007--P:netrin-activated signaling pathway
GO:0031175--P:neuron projection development
|
