dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000339
Uniprot Accession O08719; EVL_RAT;
Genbank Protein ID NP_077061.1;
Genbank Nucleotide ID NM_024147.1;
Protein Name Ena/VASP-like protein
Protein Synonyms/Alias Ena/vasodilator-stimulated phosphoprotein-like;
Gene Name Evl
Gene Synonyms/Alias Rnb6;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
130RQVQNGPSPEEMDIQPhosphoSitePlus;UniProt22135298; 22673903
150EQQHRQESLERRISAPhosphoSitePlus22135298
257KSDANRASSGGGGGGPhosphoSitePlus;UniProt22135298; 22673903
302QTEDPSTSPSPGSRAPhosphoSitePlus;UniProt22135298; 22673903
327GRKPWERSNSVEKPVcurated23984901
329KPWERSNSVEKPVSSPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521
346SRVKPAGSVNDVGLDPhosphoSitePlus;UniProt22135298; 22673903
Sequence
(Fasta)		MSEQSICQAR ASVMVYDDTS KKWVPIKPGQ QGFSRINIYH NTASNTFRVV GVKLQDQQVV 60
INYSIVKGLK YNQATPTFHQ WRDARQVYGL NFASKGEATT FSNAMLFALN IMNSQEGGPS 120
TQRQVQNGPS PEEMDIQRRQ VMEQQHRQES LERRISATGP ILPPGHPSSA ASATFSCSGP 180
PPPPPPPVPP PPTGSTPPPP PPLPAGGAQG TNHDESSASG LAAALAGAKL RRVQRPEDAS 240
GGSSPSGTSK SDANRASSGG GGGGLMEEMN KLLAKRRKAA SQTDKPADRK EDENQTEDPS 300
TSPSPGSRAT SQPPNSSEAG RKPWERSNSV EKPVSSLLSR VKPAGSVNDV GLDALDLDRM 360
KQEILEEVVR ELHKVKEEII DAIRQELSGI STT 394
Keyword

KW-0009--Actin-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0729--SH3-binding
Interpro

IPR011993--PH/PTB_dom
IPR017354--Vasodilator_phosphoprotein
IPR014885--VASP_tetra
IPR000697--WH1/EVH1_dom
PROSITE

PS50229--WH1
Pfam

PF08776--VASP_tetra
PF00568--WH1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0017124--F:SH3 domain binding
GO:0008154--P:actin polymerization or depolymerization
GO:0007411--P:axon guidance
GO:0007417--P:central nervous system development
GO:0006928--P:movement of cell or subcellular component
GO:0051289--P:protein homotetramerization