dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000338
Uniprot Accession O08717; INHBE_MOUSE; Q91XH3;
Genbank Protein ID NP_032408.2;
Genbank Nucleotide ID NM_008382.2;
Protein Name Inhibin beta E chain
Protein Synonyms/Alias Activin beta-E chain;
Gene Name Inhbe
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
58ILEGLHLTSRPRITRPhosphoSitePlus22135298
59LEGLHLTSRPRITRPPhosphoSitePlus22135298
Sequence
(Fasta)		MKLPKAQLWL ILLWALVWVQ STRSACPSCG GPTLAPQGER ALVLELAKQQ ILEGLHLTSR 60
PRITRPLPQA ALTRALRRLQ PKSMVPGNRE KVISFATIID KSTSTYRSML TFQLSPLWSH 120
HLYHARLWLH VPPSFPGTLY LRIFRCGTTR CRGFRTFLAE HQTTSSGWHA LTLPSSGLRS 180
EDSGVVKLQL EFRPLDLNST AAGLPRLLLD TAGQQRPFLE LKIRANEPGA GRARRRTPTC 240
EPETPLCCRR DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS 300
LLKANNPWPA GSSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS 351
Keyword

KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-0372--Hormone
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR029034--Cystine-knot_cytokine
IPR001318--Inhibin_betaC
IPR001839--TGF-b_C
IPR015615--TGF-beta-rel
IPR017948--TGFb_CS
PROSITE

PS00250--TGF_BETA_1
PS51362--TGF_BETA_2
Pfam

PF00019--TGF_beta
Gene Ontology

GO:0005615--C:extracellular space
GO:0005125--F:cytokine activity
GO:0005160--F:transforming growth factor beta receptor binding
GO:0048468--P:cell development
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0043408--P:regulation of MAPK cascade
GO:0060395--P:SMAD protein signal transduction