dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000335
Uniprot Accession O08710; THYG_MOUSE; O88590; Q2NKY1; Q9QWY7;
Genbank Protein ID NP_033401.2;
Genbank Nucleotide ID NM_009375.2;
Protein Name Thyroglobulin
Protein Synonyms/Alias
Gene Name Tg
Gene Synonyms/Alias Tgn;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
1658LKATSFGSLRCQVKVdbPTM 3.0;PhosphoSitePlus;curated17114649; 16381945; 23193290; 22135298; 22817900
2088LTEEKVTSDSWQTLAdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
2093VTSDSWQTLALSSVIdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298
2097SWQTLALSSVIVDPSdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
2098WQTLALSSVIVDPSIcurated21183079
2257WTGSWDATKPRASCWdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
2528AVKQFEESQGRTNSKPhosphoSitePlus22135298
Sequence
(Fasta)
MTALVLWVST LLSSVCLVAA NIFEYQVDAQ PLRPCELQRE KAFLKQAEYV PQCSEDGSFQ 60
TVQCQNDGQS CWCVDSDGRE VPGSRQLGRP TVCLSFCQLH KQRILLGSYI NSTDALYLPQ 120
CQDSGNYAPV QCDLQRVQCW CVDTEGMEVY GTRQQGRPTR CPRSCEIRNR RLLHGVGDRS 180
PPQCTADGEF MPVQCKFVNT TDMMIFDLIH NYNRFPDAFV TFSSFRGRFP EVSGYCYCAD 240
SQGRELAETG LELLLDEIYD TIFAGLDQAS TFTQSTMYRI LQRRFLAIQL VISGRFRCPT 300
KCEVEQFAAT RFGHSYIPRC HRDGHYQTVQ CQTEGMCWCV DAQGREVPGT RQQGQPPSCA 360
ADQSCALERQ QALSRFYFET PDYFSPQDLL SSEDRLAPVS GVRSDTSCPP RIKELFVDSG 420
LLRSIAVEHY QRLSESRSLL REAIRAVFPS RELAGLALQF TTNPKRLQQN LFGGTFLANA 480
AQFNLSGALG TRSTFNFSQF FQQFGLPGFL NRDRVTTLAK LLPVRLDSSS TPETLRVSEK 540
TVAMNKRVVG NFGFKVNLQE NQDALKFLVS LLELPEFLVF LQRAVSVPED IARDLGDVME 600
MVFSAQACKQ MPGKFFVPSC TAGGSYEDIQ CYAGECWCVD SRGKELDGSR VRGGRPRCPT 660
KCEKQRAQMQ SLASAQPAGS SFFVPTCTRE GYFLPVQCFN SECYCVDTEG QVIPGTQSTV 720
GEAKQCPSVC QLQAEQAFLG VVGVLLSNSS MVPSISNVYI PQCSASGQWR HVQCDGPHEQ 780
VFEWYERWKT QNGDGQELTP AALLMKIVSY REVASRNFSL FLQSLYDAGQ QRIFPVLAQY 840
PSLQDVPQVV LEGATTPPGE NIFLDPYIFW QILNGQLSQY PGPYSDFNMP LEHFNLRSCW 900
CVDEAGQKLD GTQTKPGEIP ACPGPCEEVK LRVLKFIKET EEIVSASNAS SFPLGESFLV 960
AKGIQLTSEE LDLPPQFPSR DAFSEKFLRG GEYAIRLAAQ STLTFYQSLR ASLGKSDGAA 1020
SLLWSGPYMP QCNMIGGWEP VQCHAGTGQC WCVDGRGEFI PGSLMSRSSQ MPQCPTNCEL 1080
SRASGLISAW KQAGPQRNPG PGDLFIPVCL QTGEYVRKQT SGTGTWCVDP ASGEGMPVNT 1140
NGSAQCPGLC DVLKSRALSR KVGLGYSPVC EALDGAFSPV QCDLAQGSCW CVLGSGEEVP 1200
GTRVVGTQPA CESPQCPLPF SGSDVADGVI FCETASSSGV TTVQQCQLLC RQGLRSAFSP 1260
GPLICSLESQ HWVTLPPPRA CQRPQLWQTM QTQAHFQLLL PPGKMCSVDY SGLLQAFQVF 1320
ILDELIARGF CQIQVKTFGT LVSSTVCDNS SIQVGCLTAE RLGVNVTWKL QLEDISVGSL 1380
PDLYSIERAV TGQDLLGRFA DLIQSGRFQL HLDSKTFSAD TTLYFLNGDS FVTSPRTQLG 1440
CMEGFYRVPT TRQDALGCVK CPEGSFSQDG RCTPCPAGTY QEQAGSSACI PCPRGRTTIT 1500
TGAFSKTHCV TDCQKNEAGL QCDQNGQYQA SQKNRDSGEV FCVDSEGRKL QWLQTEAGLS 1560
ESQCLMIRKF DKAPESKVIF DANSPVIVKS SVPSADSPLV QCLTDCANDE ACSFLTVSTM 1620
ESEVSCDFYS WTRDNFACVT SDQEQDAMGS LKATSFGSLR CQVKVRNSGK DSLAVYVKKG 1680
YESTAAGQKS FEPTGFQNVL SGLYSPVVFS ASGANLTDTH TYCLLACDND SCCDGFIITQ 1740
VKGGPTICGL LSSPDILLCH INDWRDTSAT QANATCAGVT YDQGSRQMTL SLGGQEFLQG 1800
LALLEGTQDS FTSFQQVYLW KDSDMGSRPE SMGCERGMVP RSDFPGDMAT ELFSPVDITQ 1860
VIVNTSHSLP SQQYWLFTHL FSAEQANLWC LSRCAQEPIF CQLADITKSS SLYFTCFLYP 1920
EAQVCDNVME SNAKNCSQIL PHQPTALFRR KVVLNDRVKN FYTRLPFQKL TGISIRDKVP 1980
MSGKLISNGF FECERLCDRD PCCTGFGFLN VSQLQGGEVT CLTLNSMGIQ TCNEESGATW 2040
RILDCGSEDT EVHTYPFGWY QKPAVWSDTP SFCPSAALQS LTEEKVTSDS WQTLALSSVI 2100
VDPSIKHFDV AHISTAATSN FSMAQDFCLQ QCSRHQDCLV TTLQIQPGVV RCVFYPDIQN 2160
CIHSLRSHTC WLLLHEEATY IYRKSGIPLV QSDVTSTPSV RIDSFGQLQG GSQVIKVGTA 2220
WKQVYRFLGV PYAAPPLADN RFRAPEVLNW TGSWDATKPR ASCWQPGTRT PTPPQINEDC 2280
LYLNVFVPEN LVSNASVLVF FHNTMEMEGS GGQLTIDGSI LAAVGNFIVV TANYRLGVFG 2340
FLSSGSDEVA GNWGLLDQVA ALTWVQSHIG AFGGDPQRVT LAADRSGADV ASIHLLISRP 2400
TRLQLFRKAL LMGGSALSPA AIISPERAQQ QAAALAKEVG CPTSSIQEVV SCLRQKPANI 2460
LNDAQTKLLA VSGPFHYWGP VVDGQYLREL PSRRLKRPLP VKVDLLIGGS QDDGLINRAK 2520
AVKQFEESQG RTNSKTAFYQ ALQNSLGGED SDARILAAAV WYYSLEHSTD DYASFSRALE 2580
NATRDYFIIC PMVNMASLWA RRTRGNVFMY HVPESYGHGS LELLADVQYA FGLPFYSAYQ 2640
GQFSTEEQSL SLKVMQYFSN FIRSGNPNYP HEFSRKAAEF ATPWPDFIPG AGGESYKELS 2700
AQLPNRQGLK QADCSFWSKY IQTLKDADGA KDAQLTKSEE EDLEVGPGLE EDLSGSLEPV 2760
PKSYSK 2767
Keyword

KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0372--Hormone
KW-0405--Iodination
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0765--Sulfation
KW-0795--Thyroid hormone
KW-0893--Thyroid hormones biosynthesis

Interpro

IPR029058--AB_hydrolase
IPR002018--CarbesteraseB
IPR019819--Carboxylesterase_B_CS
IPR016324--Thyroglobulin
IPR000716--Thyroglobulin_1
IPR011641--Tyr-kin_ephrin_A/B_rcpt-like

PROSITE

PS00941--CARBOXYLESTERASE_B_2
PS00484--THYROGLOBULIN_1_1
PS51162--THYROGLOBULIN_1_2

Pfam

PF00135--COesterase
PF07699--GCC2_GCC3
PF00086--Thyroglobulin_1

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0043168--F:anion binding
GO:0042446--P:hormone biosynthetic process
GO:0015705--P:iodide transport
GO:0031641--P:regulation of myelination
GO:0032496--P:response to lipopolysaccharide
GO:0009268--P:response to pH
GO:0030878--P:thyroid gland development
GO:0042403--P:thyroid hormone metabolic process
GO:0045056--P:transcytosis