dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000334
Uniprot Accession O08709; PRDX6_MOUSE; Q91WT2; Q9QWP4; Q9QWW0;
Genbank Protein ID NP_031479.1; XP_006544594.1;
Genbank Nucleotide ID NM_007453.4; XM_006544531.2;
Protein Name Peroxiredoxin-6
Protein Synonyms/Alias 1-Cys peroxiredoxin;1-Cys PRX;Acidic calcium-independent phospholipase A2;aiPLA2;
Gene Name Prdx6
Gene Synonyms/Alias Aop2;Ltw4;Prdx5;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
18APNFEANTTIGRIRFcurated23984901
44FSHPRDFTPVCTTELdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17242355; 20415495; 21183079; 16381945; 23193290; 21081558;
75LIALSIDSVEDHLAWPhosphoPep 2.0;curated19060867; 23984901
83VEDHLAWSKDINAYNdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
89WSKDINAYNGETPTEdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18034455; 16381945; 23193290; 22135298; 19366988; 25195567;
93INAYNGETPTEKLPFdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17203969; 16381945; 23193290; 21183079; 21081558; 19060867;
95AYNGETPTEKLPFPIdbPTM 3.0;SysPTM 2.0;curated17203969; 16381945; 23193290; 19366988; 21743459; 22817900
177TGTKPVATPVDWKKGdbPTM 3.0;PhosphoSitePlus21262967; 16381945; 23193290; 22135298
186VDWKKGESVMVVPTLPhosphoSitePlus22135298
194VMVVPTLSEEEAKQCdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated20415495; 16381945; 23193290; 21081558; 22135298; 22817900;
Sequence
(Fasta)		MPGGLLLGDE APNFEANTTI GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE 60
FAKRNVKLIA LSIDSVEDHL AWSKDINAYN GETPTEKLPF PIIDDKGRDL AILLGMLDPV 120
EKDDNNMPVT ARVVFIFGPD KKLKLSILYP ATTGRNFDEI LRVVDSLQLT GTKPVATPVD 180
WKKGESVMVV PTLSEEEAKQ CFPKGVFTKE LPSGKKYLRY TPQP 225
Keyword

KW-0007--Acetylation
KW-0049--Antioxidant
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0458--Lysosome
KW-0511--Multifunctional enzyme
KW-0560--Oxidoreductase
KW-0575--Peroxidase
KW-0597--Phosphoprotein
KW-0676--Redox-active center
KW-1185--Reference proteome
Interpro

IPR000866--AhpC/TSA
IPR024706--Peroxiredoxin_AhpC-typ
IPR019479--Peroxiredoxin_C
IPR012336--Thioredoxin-like_fold
PROSITE

PS51352--THIOREDOXIN_2
Pfam

PF10417--1-cysPrx_C
PF00578--AhpC-TSA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005764--C:lysosome
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0004602--F:glutathione peroxidase activity
GO:0004601--F:peroxidase activity
GO:0051920--F:peroxiredoxin activity
GO:0004623--F:phospholipase A2 activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0032060--P:bleb assembly
GO:0009395--P:phospholipid catabolic process
GO:0006979--P:response to oxidative stress
GO:0000302--P:response to reactive oxygen species