| Tag |
Content |
| dbPAF ID |
dbPAF-0000331 |
| Uniprot Accession |
O08699; PGDH_RAT; Q6P687;
|
| Genbank Protein ID |
NP_077366.2;
|
| Genbank Nucleotide ID |
NM_024390.2;
|
| Protein Name |
15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
| Protein Synonyms/Alias |
|
| Gene Name |
Hpgd |
| Gene Synonyms/Alias |
Pgdh1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).Functional Description
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 188 | ICPGFVKTPILESIE | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MHVNGKVALV TGAAQGIGKA FTEALLLHGA KVALVDWNLE TGVKCKAALD EQFEPQKTLF 60
IQCDVADQKQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EQTLQINLVS VISGTYLGLD 120
YMSKQNGGEG GIIINISSIA GLMPVAQQPV YCASKHGIIG FTRSAAMAAN LMKSGVRLNV 180
ICPGFVKTPI LESIEKEENM GQYIEYTDQI KAMMKFYGIL DPSAIANGLI NLIEDDALNG 240
AIMKITASKG IHFQDYDLFP SFSKAP
267Fasta Sequence
>O08699|Hpgd|Rattus norvegicus(Rat)
MHVNGKVALVTGAAQGIGKAFTEALLLHGAKVALVDWNLETGVKCKAALDEQFEPQKTLFIQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINISSIAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVKTPILESIEKEENMGQYIEYTDQIKAMMKFYGILDPSAIANGLINLIEDDALNGAIMKITASKGIHFQDYDLFPSFSKAP
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0276--Fatty acid metabolism
KW-0443--Lipid metabolism
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0644--Prostaglandin metabolism
KW-1185--Reference proteome
KW-0043--Tumor suppressor
|
| Interpro |
IPR002198--DH_sc/Rdtase_SDR
IPR002347--Glc/ribitol_DH
IPR016040--NAD(P)-bd_dom
IPR020904--Sc_DH/Rdtase_CS
|
| PROSITE |
PS00061--ADH_SHORT
|
| Pfam |
PF00106--adh_short
|
| Gene Ontology |
GO:0016323--C:basolateral plasma membrane
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016404--F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0003824--F:catalytic activity
GO:0051287--F:NAD binding
GO:0070403--F:NAD+ binding
GO:0004957--F:prostaglandin E receptor activity
GO:0097070--P:ductus arteriosus closure
GO:0007565--P:female pregnancy
GO:0045786--P:negative regulation of cell cycle
GO:0030728--P:ovulation
GO:0007567--P:parturition
GO:0006693--P:prostaglandin metabolic process
GO:0070493--P:thrombin receptor signaling pathway
GO:0007179--P:transforming growth factor beta receptor signaling pathway
|
