| Tag |
Content |
| dbPAF ID |
dbPAF-0000330 |
| Uniprot Accession |
O08697; ARL2_RAT;
|
| Genbank Protein ID |
NP_113899.1;
|
| Genbank Nucleotide ID |
NM_031711.1;
|
| Protein Name |
ADP-ribosylation factor-like protein 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
Arl2 |
| Gene Synonyms/Alias |
Arl184; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (By similarity).Functional Description
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MGLLTILKKM KQKERDVRLL MLGLDNAGKT TILKKFNGED VDTISPTLGF NIKTLEHRGF 60
KLNIWDVGGQ KSLRSYWRNY FESTDGLIWV VDSADRQRMQ DCQRELQSLL VEERLAGATL 120
LIFANKQDLP GALSCNAIQE ALELDSIRSH HWRIQGCSAV TGEDLLPGID WLLDDISSRV 180
FTAD
185Fasta Sequence
>O08697|Arl2|Rattus norvegicus(Rat)
MGLLTILKKMKQKERDVRLLMLGLDNAGKTTILKKFNGEDVDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSCNAIQEALELDSIRSHHWRIQGCSAVTGEDLLPGIDWLLDDISSRVFTAD
|
| Keyword |
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0342--GTP-binding
KW-1017--Isopeptide bond
KW-0449--Lipoprotein
KW-0496--Mitochondrion
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
|
| Interpro |
IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR024156--Small_GTPase_ARF
IPR006689--Small_GTPase_ARF/SAR
|
| PROSITE |
PS51417--ARF
|
| Pfam |
PF00025--Arf
|
| Gene Ontology |
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0016328--C:lateral plasma membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005634--C:nucleus
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0015870--P:acetylcholine transport
GO:0070830--P:bicellular tight junction assembly
GO:0007049--P:cell cycle
GO:0051297--P:centrosome organization
GO:0051457--P:maintenance of protein location in nucleus
GO:0034260--P:negative regulation of GTPase activity
GO:0010811--P:positive regulation of cell-substrate adhesion
GO:0031116--P:positive regulation of microtubule polymerization
GO:0031113--P:regulation of microtubule polymerization
GO:0007264--P:small GTPase mediated signal transduction
|
