Tag |
Content |
dbPAF ID |
dbPAF-0000329 |
Uniprot Accession |
O08696; FOXM1_MOUSE; |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Forkhead box protein M1 |
Protein Synonyms/Alias |
Forkhead homolog 16;Winged-helix transcription factor Trident; |
Gene Name |
Foxm1 |
Gene Synonyms/Alias |
Fkh16; |
Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.Functional Description
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
|
Phosphorylation Sites
|
dbPAF PTMs: 12 |
Sequence (Fasta) | MRTSPRRPLI LKRRRLPLPV QNAPSETSEE EAKRSPAQPE PAPAQASQEV AESSSCKFPA 60 GIKIINHPTT PNTQVVAIPS NADIQSIITA LTAKGKESGT SGPNRFILIS SGGPSSHPSQ 120 PQAHSSRDSK RAEVITETLG PKPAAKGVPV PKPPGAPPRQ RQESYAGGEA AGCTLDNSLT 180 NIQWLGKMSS DGLGPCSVKQ ELEEKENCHL EQNRVKVEEP SGVSTSWQDS VSERPPYSYM 240 AMIQFAINST ERKRMTLKDI YTWIEDHFPY FKHIAKPGWK NSIRHNLSLH DMFVRETSAN 300 GKVSFWTIHP SANRHLTLDQ VFKPLEPGSP QSPEHLESQQ KRPNPELHRN VTIKTEIPLG 360 ARRKMKPLLP RVSSYLEPIQ FPVNQSLVLQ PSVKVPFRLA ASLMSSELAR HSKRVRIAPK 420 VLLSSEGIAP LPATEPPKEE KPLLGGEGLL PLLPIQSIKE EEMQPEEDIA HLERPIKVES 480 PPLEEWPSPC ASLKEELSNS WEDSSCSPTP KPKKSYCGLK SPTRCVSEML VTKRREKREV 540 SRSRRKQHLQ PPCLDEPDLF FPEDSSTFRP AVELLAESSE PAPHLSCPQE EGGPFKTPIK 600 ETLPVSSTPS KSVLSRDPES WRLTPPAKVG GLDFSPVRTP QGAFGLLPDS LGLMELNTTP 660 LKSGPLFDSP RELLNSEPFD LASDPFGSPP PPHVEGPKPG SPELQIPSLS ANRSLTEGLV 720 LDTMNDSLSK ILLDISFPGL EEDPLGPDNI NWSQFIPELR
761Fasta Sequence
>O08696|Foxm1|Mus musculus(Mouse) MRTSPRRPLILKRRRLPLPVQNAPSETSEEEAKRSPAQPEPAPAQASQEVAESSSCKFPAGIKIINHPTTPNTQVVAIPSNADIQSIITALTAKGKESGTSGPNRFILISSGGPSSHPSQPQAHSSRDSKRAEVITETLGPKPAAKGVPVPKPPGAPPRQRQESYAGGEAAGCTLDNSLTNIQWLGKMSSDGLGPCSVKQELEEKENCHLEQNRVKVEEPSGVSTSWQDSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRHLTLDQVFKPLEPGSPQSPEHLESQQKRPNPELHRNVTIKTEIPLGARRKMKPLLPRVSSYLEPIQFPVNQSLVLQPSVKVPFRLAASLMSSELARHSKRVRIAPKVLLSSEGIAPLPATEPPKEEKPLLGGEGLLPLLPIQSIKEEEMQPEEDIAHLERPIKVESPPLEEWPSPCASLKEELSNSWEDSSCSPTPKPKKSYCGLKSPTRCVSEMLVTKRREKREVSRSRRKQHLQPPCLDEPDLFFPEDSSTFRPAVELLAESSEPAPHLSCPQEEGGPFKTPIKETLPVSSTPSKSVLSRDPESWRLTPPAKVGGLDFSPVRTPQGAFGLLPDSLGLMELNTTPLKSGPLFDSPRELLNSEPFDLASDPFGSPPPPHVEGPKPGSPELQIPSLSANRSLTEGLVLDTMNDSLSKILLDISFPGLEEDPLGPDNINWSQFIPELR
|
Keyword |
KW-0010--Activator KW-0131--Cell cycle KW-0181--Complete proteome KW-0227--DNA damage KW-0234--DNA repair KW-0238--DNA-binding KW-1017--Isopeptide bond KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation
|
Interpro |
IPR001766--Fork_head_dom IPR018122--TF_fork_head_CS_1 IPR011991--WHTH_DNA-bd_dom
|
PROSITE |
PS00657--FORK_HEAD_1 PS00658--FORK_HEAD_2 PS50039--FORK_HEAD_3
|
Pfam |
PF00250--Forkhead
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0003677--F:DNA binding GO:0019901--F:protein kinase binding GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0043565--F:sequence-specific DNA binding GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0044212--F:transcription regulatory region DNA binding GO:0009653--P:anatomical structure morphogenesis GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006281--P:DNA repair GO:0000086--P:G2/M transition of mitotic cell cycle GO:0001889--P:liver development GO:0090344--P:negative regulation of cell aging GO:0032873--P:negative regulation of stress-activated MAPK cascade GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0008284--P:positive regulation of cell proliferation GO:2000781--P:positive regulation of double-strand break repair GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0045893--P:positive regulation of transcription, DNA-templated GO:0071156--P:regulation of cell cycle arrest GO:0042127--P:regulation of cell proliferation GO:0046578--P:regulation of Ras protein signal transduction GO:2000377--P:regulation of reactive oxygen species metabolic process GO:0006355--P:regulation of transcription, DNA-templated GO:0006366--P:transcription from RNA polymerase II promoter GO:0001570--P:vasculogenesis
|