dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000329
Uniprot Accession O08696; FOXM1_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Forkhead box protein M1
Protein Synonyms/Alias Forkhead homolog 16;Winged-helix transcription factor Trident;
Gene Name Foxm1
Gene Synonyms/Alias Fkh16;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
Phosphorylation Sites
dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
270WIEDHFPYFKHIAKPPhosphoSitePlus22135298
515PTPKPKKSYCGLKSPcurated25266776
521KSYCGLKSPTRCVSEcurated25266776; 25338131
523YCGLKSPTRCVSEMLcurated23984901
608ETLPVSSTPSKSVLScurated25266776
624DPESWRLTPPAKVGGcurated25266776
635KVGGLDFSPVRTPQGdbPTM 3.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 22135298; 23984901; 25338131
663LNTTPLKSGPLFDSPdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
669KSGPLFDSPRELLNSdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated17242355; 16381945; 23193290; 22135298; 19366988; 22817900
714PSLSANRSLTEGLVLdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19854140; 21183079; 16381945; 23193290; 19060867; 22135298;
727VLDTMNDSLSKILLDdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 25338131
729DTMNDSLSKILLDISPhosphoPep 2.0;curated19060867; 25266776; 21183079
Sequence
(Fasta)
MRTSPRRPLI LKRRRLPLPV QNAPSETSEE EAKRSPAQPE PAPAQASQEV AESSSCKFPA 60
GIKIINHPTT PNTQVVAIPS NADIQSIITA LTAKGKESGT SGPNRFILIS SGGPSSHPSQ 120
PQAHSSRDSK RAEVITETLG PKPAAKGVPV PKPPGAPPRQ RQESYAGGEA AGCTLDNSLT 180
NIQWLGKMSS DGLGPCSVKQ ELEEKENCHL EQNRVKVEEP SGVSTSWQDS VSERPPYSYM 240
AMIQFAINST ERKRMTLKDI YTWIEDHFPY FKHIAKPGWK NSIRHNLSLH DMFVRETSAN 300
GKVSFWTIHP SANRHLTLDQ VFKPLEPGSP QSPEHLESQQ KRPNPELHRN VTIKTEIPLG 360
ARRKMKPLLP RVSSYLEPIQ FPVNQSLVLQ PSVKVPFRLA ASLMSSELAR HSKRVRIAPK 420
VLLSSEGIAP LPATEPPKEE KPLLGGEGLL PLLPIQSIKE EEMQPEEDIA HLERPIKVES 480
PPLEEWPSPC ASLKEELSNS WEDSSCSPTP KPKKSYCGLK SPTRCVSEML VTKRREKREV 540
SRSRRKQHLQ PPCLDEPDLF FPEDSSTFRP AVELLAESSE PAPHLSCPQE EGGPFKTPIK 600
ETLPVSSTPS KSVLSRDPES WRLTPPAKVG GLDFSPVRTP QGAFGLLPDS LGLMELNTTP 660
LKSGPLFDSP RELLNSEPFD LASDPFGSPP PPHVEGPKPG SPELQIPSLS ANRSLTEGLV 720
LDTMNDSLSK ILLDISFPGL EEDPLGPDNI NWSQFIPELR 761
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR001766--Fork_head_dom
IPR018122--TF_fork_head_CS_1
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS00657--FORK_HEAD_1
PS00658--FORK_HEAD_2
PS50039--FORK_HEAD_3

Pfam

PF00250--Forkhead

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0019901--F:protein kinase binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0009653--P:anatomical structure morphogenesis
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006281--P:DNA repair
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0001889--P:liver development
GO:0090344--P:negative regulation of cell aging
GO:0032873--P:negative regulation of stress-activated MAPK cascade
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0008284--P:positive regulation of cell proliferation
GO:2000781--P:positive regulation of double-strand break repair
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0071156--P:regulation of cell cycle arrest
GO:0042127--P:regulation of cell proliferation
GO:0046578--P:regulation of Ras protein signal transduction
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0001570--P:vasculogenesis