| Tag |
Content |
| dbPAF ID |
dbPAF-0000328 |
| Uniprot Accession |
O08692; NGP_MOUSE; Q61903;
|
| Genbank Protein ID |
NP_032720.2;
|
| Genbank Nucleotide ID |
NM_008694.2;
|
| Protein Name |
Neutrophilic granule protein |
| Protein Synonyms/Alias |
|
| Gene Name |
Ngp |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis.Functional Description
Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 108 | KFFRRRQSTSLTLTC | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MAGLWKTFVL VVALAVVSCE ALRQLRYEEI VDRAIEAYNQ GRQGRPLFRL LSATPPSSQN 60
PATNIPLQFR IKETECTSTQ ERQPKDCDFL EDGEERNCTG KFFRRRQSTS LTLTCDRDCS 120
REDTQETSFN DKQDVSEKEK FEDVPPHIRN IYEDAKYDII GNILKNF
168Fasta Sequence
>O08692|Ngp|Mus musculus(Mouse)
MAGLWKTFVLVVALAVVSCEALRQLRYEEIVDRAIEAYNQGRQGRPLFRLLSATPPSSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTGKFFRRRQSTSLTLTCDRDCSREDTQETSFNDKQDVSEKEKFEDVPPHIRNIYEDAKYDIIGNILKNF
|
| Keyword |
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
KW-0789--Thiol protease inhibitor
KW-0043--Tumor suppressor
|
| Interpro |
IPR001894--Cathelicidin
IPR000010--Cystatin_dom
|
| PROSITE |
|
| Pfam |
PF00666--Cathelicidins
|
| Gene Ontology |
GO:0031410--C:cytoplasmic vesicle
GO:0005615--C:extracellular space
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0006952--P:defense response
GO:0016525--P:negative regulation of angiogenesis
GO:0010951--P:negative regulation of endopeptidase activity
GO:1901491--P:negative regulation of lymphangiogenesis
|
