dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000321 |
| Uniprot Accession | O08678; MARK1_RAT; |
| Genbank Protein ID | NP_446399.1; |
| Genbank Nucleotide ID | NM_053947.1; |
| Protein Name | Serine/threonine-protein kinase MARK1 |
| Protein Synonyms/Alias | |
| Gene Name | Mark1 |
| Gene Synonyms/Alias | |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MSARTPLPTV NERDTENHTS VDGYTETHIP PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 60 RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120 KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKCIVH 180 RDLKAENLLL DADMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240 WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRVPFYM STDCENLLKK LLVLNPIKRG 300 SLEQIMKDRW MNVGHEEEEL KPYSEPELDL NDAKRIDIMV TMGFARDEIN DALVSQKYDE 360 VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 420 RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDTARR LGSTTVGSKS EVTASPLVGP 480 DRKKSSAGPS NNVYSGGSMT RRNTYVCERS TDRYAALQNG RDSSLTEMSA SSMSSTGSTV 540 ASAGPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGT AQRVPAASPS AHSISASTPD 600 RTRFPRGSSS RSTFHGEQLR ERRSAAYSGP PASPSHDTAA LAHARRGTST GIISKITSKF 660 VRRDPSEGEA SGRTDTARGS SGEPKDKEEG KEAKPRSLRF TWSMKTTSSM DPNDMVREIR 720 KVLDANTCDY EQRERFLLFC VHGDARQDSL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF 780 KNIASKIANE LKL 794 |
| Keyword | KW-0067--ATP-binding |
| Interpro | IPR028375--KA1/Ssp2_C |
| PROSITE | PS50032--KA1 |
| Pfam | |
| Gene Ontology | GO:0005737--C:cytoplasm |