| Tag |
Content |
| dbPAF ID |
dbPAF-0000317 |
| Uniprot Accession |
O08665; SEM3A_MOUSE; E9QK85; Q5BL08; Q62180; Q62215;
|
| Genbank Protein ID |
NP_001230001.1; NP_001230002.1; NP_033178.2; XP_006503620.1; XP_006503621.1; XP_006503622.1; XP_011238967.1;
|
| Genbank Nucleotide ID |
NM_001243072.1; NM_001243073.1; NM_009152.4; XM_006503557.2; XM_006503558.2; XM_006503559.1; XM_011240665.1;
|
| Protein Name |
Semaphorin-3A |
| Protein Synonyms/Alias |
Semaphorin III;Sema III;Semaphorin-D;Sema D; |
| Gene Name |
Sema3a |
| Gene Synonyms/Alias |
Semad;SemD; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity).Functional Description
Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MGWFTGIACL FWGVLLTARA NYANGKNNVP RLKLSYKEML ESNNVITFNG LANSSSYHTF 60
LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR DECKWAGKDI LKECANFIKV 120
LEAYNQTHLY ACGTGAFHPI CTYIEVGHHP EDNIFKLQDS HFENGRGKSP YDPKLLTASL 180
LIDGELYSGT AADFMGRDFA IFRTLGHHHP IRTEQHDSRW LNDPRFISAH LIPESDNPED 240
DKVYFFFREN AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG 300
IDTHFDELQD VFLMNSKDPK NPIVYGVFTT SSNIFKGSAV CMYSMSDVRR VFLGPYAHRD 360
GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI TFARSHPAMY NPVFPINNRP 420
IMIKTDVNYQ FTQIVVDRVD AEDGQYDVMF IGTDVGTVLK VVSVPKETWH DLEEILLEEM 480
TVFREPTTIS AMELSTKQQQ LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS 540
SCSRYFPTAK RRTRRQDIRN GDPLTHCSDL QHHDNHHGPS LEERIIYGVE NSSTFLECSP 600
KSQRALVYWQ FQRRNEDRKE EIRMGDHIIR TEQGLLLRSL QKKDSGNYLC HAVEHGFMQT 660
LLKVTLEVID TEHLEELLHK DDDGDGSKIK EMSSSMTPSQ KVWYRDFMQL INHPNLNTMD 720
EFCEQVWKRD RKQRRQRPGH SQGSSNKWKH MQESKKGRNR RTHEFERAPR SV
773Fasta Sequence
>O08665|Sema3a|Mus musculus(Mouse)
MGWFTGIACLFWGVLLTARANYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEILLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub
IPR016201--Plexin-like_fold
IPR001627--Semap_dom
IPR027231--Semaphorin
IPR015943--WD40/YVTN_repeat-like_dom
|
| PROSITE |
PS50835--IG_LIKE
PS51004--SEMA
|
| Pfam |
PF01403--Sema
|
| Gene Ontology |
GO:0030424--C:axon
GO:0030425--C:dendrite
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0045499--F:chemorepellent activity
GO:0038191--F:neuropilin binding
GO:0030215--F:semaphorin receptor binding
GO:0006915--P:apoptotic process
GO:0048846--P:axon extension involved in axon guidance
GO:0007411--P:axon guidance
GO:0007413--P:axonal fasciculation
GO:0060385--P:axonogenesis involved in innervation
GO:0021785--P:branchiomotor neuron axon guidance
GO:0048813--P:dendrite morphogenesis
GO:0060666--P:dichotomous subdivision of terminal units involved in salivary gland branching
GO:0021612--P:facial nerve structural organization
GO:1903375--P:facioacoustic ganglion development
GO:0021828--P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0008045--P:motor neuron axon guidance
GO:0050919--P:negative chemotaxis
GO:0030517--P:negative regulation of axon extension
GO:0048843--P:negative regulation of axon extension involved in axon guidance
GO:0010633--P:negative regulation of epithelial cell migration
GO:0021675--P:nerve development
GO:1901166--P:neural crest cell migration involved in autonomic nervous system development
GO:1903045--P:neural crest cell migration involved in sympathetic nervous system development
GO:0001764--P:neuron migration
GO:0021772--P:olfactory bulb development
GO:2000020--P:positive regulation of male gonad development
GO:2001224--P:positive regulation of neuron migration
GO:0048841--P:regulation of axon extension involved in axon guidance
GO:0002027--P:regulation of heart rate
GO:0071526--P:semaphorin-plexin signaling pathway
GO:1902287--P:semaphorin-plexin signaling pathway involved in axon guidance
GO:1902285--P:semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:0061549--P:sympathetic ganglion development
GO:0097490--P:sympathetic neuron projection extension
GO:0097491--P:sympathetic neuron projection guidance
GO:0061551--P:trigeminal ganglion development
GO:0021637--P:trigeminal nerve structural organization
GO:0036486--P:ventral trunk neural crest cell migration
|
