dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000315
Uniprot Accession O08663; MAP2_MOUSE;
Genbank Protein ID NP_062622.1; XP_006513959.1; XP_006513960.1;
Genbank Nucleotide ID NM_019648.3; XM_006513896.2; XM_006513897.2;
Protein Name Methionine aminopeptidase 2
Protein Synonyms/Alias
Gene Name Metap2
Gene Synonyms/Alias Mnpep;P67eif2;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
9AGVEQAASFGGHLNGPhosphoSitePlus22135298
27PDDREEGTSSTAEEASysPTM 2.0;curated18846507; 19366988; 25266776; 22817900
28DDREEGTSSTAEEAAcurated25338131
29DREEGTSSTAEEAAKcurated25266776; 25338131
30REEGTSSTAEEAAKKSysPTM 2.0;curated18846507; 19366988; 22817900
50KKGKGAVSAVQQELDcurated23984901; 25338131
Sequence
(Fasta)		MAGVEQAASF GGHLNGDLDP DDREEGTSST AEEAAKKKRR KKKKGKGAVS AVQQELDKES 60
GALVDEVAKQ LESQALEEKE RDDDDEDGDG DADGATGKKK KKKKKKRGPK VQTDPPSVPI 120
CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR 180
KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP TGCSLNNCAA HYTPNAGDTT 240
VLQYDDICKI DFGTHISGRI IDCAFTVTFN PKYDILLTAV KDATNTGIKC AGIDVRLCDV 300
GEAIQEVMES YEVEIDGKTY QVKPIRNLNG HSIGPYRIHA GKTVPIVKGG EATRMEEGEV 360
YAIETFGSTG KGVVHDDMEC SHYMKNFDVG HVPIRLPRTK HLLNVINENF GTLAFCRRWL 420
DRLGESKYLM ALKNLCDLGI VDPYPPLCDI KGSYTAQFEH TILLRPTCKE VVSRGDDY 479
Keyword

KW-0007--Acetylation
KW-0031--Aminopeptidase
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
Interpro

IPR001714--Pept_M24_MAP
IPR000994--Pept_M24_structural-domain
IPR002468--Pept_M24A_MAP2
IPR018349--Pept_M24A_MAP2_BS
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01202--MAP_2
Pfam

PF00557--Peptidase_M24
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004177--F:aminopeptidase activity
GO:0046872--F:metal ion binding
GO:0070006--F:metalloaminopeptidase activity
GO:0008235--F:metalloexopeptidase activity
GO:0044822--F:poly(A) RNA binding
GO:0031365--P:N-terminal protein amino acid modification
GO:0018206--P:peptidyl-methionine modification
GO:0070084--P:protein initiator methionine removal
GO:0016485--P:protein processing