dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000314 |
| Uniprot Accession | O08662; PI4KA_RAT; |
| Genbank Protein ID | NP_071637.1; |
| Genbank Nucleotide ID | NM_022301.1; |
| Protein Name | Phosphatidylinositol 4-kinase alpha |
| Protein Synonyms/Alias | |
| Gene Name | Pi4ka |
| Gene Synonyms/Alias | Pik4ca; |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. |
| Phosphorylation Sites |
dbPAF PTMs: 7 |
| Sequence (Fasta) | MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDCIVP YLLRLLRGLP KVYWVEESTA 60 RKGRGNLPVA ESFSFCLVTL LSDVACRDPS LRDEILEALL QVLHVLLGMC QALEIQEKEY 120 LCKYAIPCLI GISKSFGRYS NSEESLLSKL FPKVPPHSLR IPEELEGVRR RSFNDFRSIL 180 PSNLLTVCQE GTLKRKTSSV SSISQVSPER GMPPPSSPGG SAFHYFEASC LPDGTTLEPE 240 YYFSTISSSF SVSPLFNGIT YKEFYIPLEM LRELLNLVKK IVEEPVLKSL DAAVARVMEA 300 NPSADLYYTT FSDPVYLTMF KMLRDTLYYM KDLPTSFVKE IHDFVLEQFN MSQGELQKIL 360 HDADRIHSEM SPLKLRCQAN AACVDLMVWA VKDEQGAENL CIKLSEKLQS KTSSKVIIAH 420 LPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVIPSPVL VKLYKYHSQY HTVAGSDIKI 480 SVTNEHSEST LNVLPGKKNQ PSMYEQLRDI AIDNICRCLK AGLTVDPVIV EAFLASLSNR 540 LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QQKFCQPPSP LDVLIIDQLG 600 CLVITGNQYI YQEVWNLFQQ ISVKASSVVY SATKDYKDHG YRHCSLAVIN ALANIAANIQ 660 EEHLVDELLM NLLELFVQLG LEGKRASERA SEKGPALKAS SSAGNLGVLI PVIAVLTRRL 720 PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE GVCEIATKSP LLTFPSKEPL 780 RSVLQYNSAM KNDTVTPAEL NELRSTIINL LDPPPEVSAL INKLDFAMST YLLSVYRLEY 840 MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG MMQCVIAVAD KVFDAFLNMM AEKAKTKENE 900 EELERHAQFL LVNFNHIHKR IRRVADKYLS GLVDKFPHLL WSGTVLKTML DILQTLSLSL 960 SADIHKDQPY YDIPDAPYRI TVPDTYEARE SIVKDFAARC GMILQEAMKW APTVTKSHLQ 1020 EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG VTQLTERPAC VKKDYSNFMA 1080 SLNLRNRYAG EVHGMIRFSG ATGQMSDLNK MMVQDLITAL DHSHPQHYTQ AMFKLTAMLI 1140 SSKDCDPQLL HHLCWGPLRM FNEHGMETAL ACWEWLLAGK NGVEVPFMRE MAGAWHMTVE 1200 QKFGLFSAET KEADPLAASE ASQPRPCPPE VTPHYIWIDF LVQRFEIAKY CSSDQVEIFS 1260 SLLQRSMSLH IGGARGSMNR HVAAIGPRFK LLTLGLSLLH ADVVPNATIR NVLREKIYST 1320 AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL TASQLVPPDN QDTRSNLDIT 1380 VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL HKYYMKRRTL LLSLLATEIE 1440 RLITWYNPLS APELELDQAG ENSVANWRSK YISLSEKQWK DNVNLAWTIS PYLAVQLPAR 1500 FKNTEAIGNE VTRLVRLDPG AVSDVPEAIK FLVTWHTIDA DAPELSHVLC WAPTDPPTGL 1560 SYFSSMYPPH PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL RYDKMGYVRE YILWAAAKSQ 1620 LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LEQLVEEITG SLSGPAKDFY QREFDFFNKI 1680 TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE AIVLDIDYKS GTPMQSAAKA 1740 PYLAKFKVKR CGVSELEKEG LQCRSDTEDE CRRQEADGKK ICWQAAIFKV GDDCRQDMLA 1800 LQIIDLFKNI FQLVGLDLFV FPYRVVATAP GCGVIECIPD CTSRDQLGRQ TDFGMYDYFT 1860 RQYGDESTLA FQQARYNFIR SMAAYSLLLF LLQIKDRHNG NIMLDKKGHI IHIDFGFMFE 1920 SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV RGYLAVRPYM DAVVSLVTLM 1980 LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKIIQNC FLSNRSRTYD MIQYYQNDIP 2040 Y 2042 |
| Keyword | KW-0067--ATP-binding |
| Interpro | IPR016024--ARM-type_fold |
| PROSITE | PS00915--PI3_4_KINASE_1 |
| Pfam | |
| Gene Ontology | GO:0005737--C:cytoplasm |