dbPAF Protein Information
| Tag | Content | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000311 | ||||||||||||||||
| Uniprot Accession | O08653; TEP1_RAT; | ||||||||||||||||
| Genbank Protein ID | NP_072113.1; | ||||||||||||||||
| Genbank Nucleotide ID | NM_022591.2; | ||||||||||||||||
| Protein Name | Telomerase protein component 1 | ||||||||||||||||
| Protein Synonyms/Alias | |||||||||||||||||
| Gene Name | Tep1 | ||||||||||||||||
| Gene Synonyms/Alias | Tlp1; | ||||||||||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||||||||||
| NCBI Taxa ID | 10116 | ||||||||||||||||
| Functional Description (View all) |
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). | ||||||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 3
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| Sequence (Fasta) | MEKLCGYVPV HPDILSLKNR CLTMLSDIQP LEKIHGQRSV NPDILSLENR CLTLLPDLQP 60 MEKIHGQRSV HPDILSSENR CLTLLPDLQS LEKLCGHMSS HPDVLSLENR CLATLPTVKR 120 TVSSGPLLQC LHRSHTAQAD LRDPNFRNCL FPEPPTIEAP CFLKELDLPT GPRALKSMSA 180 TARVQEVALG QRCVSEGKEL QEEKESAEVP MPLYSLSLGG EEEEVVGAPV LKLTSGDSDS 240 HPETTDQILQ EKKMALLTLL CSAMASSVNV KDASDPTRAS IHEVCSALAP LEPEFILKAS 300 LYARQQLNLR DIANIVLAVA ALLPACRPHV RRYYSAIVHL PSDWIQVAEF YQSLAEGDEK 360 KLVPLPACLR AAMTDKFAQF DEYQLAKYNP RKHRSKTRSR QPPRPQRTKP PFSESGKCFP 420 KSVWPLKNEQ ISFEAAYNAV SEKKRLPRFT LKKLVEQLHI HEPAQHVQAL LGYRYPSTLE 480 LFSRSHLPGP WDSSRAGQRM KLQRPETWER ELSLRGNRAS VWEELIDNGK LPFMAMLRNL 540 CNLLRTGISA HHHELVLQRL QHEKSVIHSR QFPFRFLNAH DSLDRLEAQL RSKASPFPSN 600 TTLMKRIMIR NSKKIKRPAN PRYLCTLTQR QLRAAMAIPV MYEHLKREKL RLHKARQWTC 660 DLELLERYRQ ALETAVNISV KHNLPPLPGR TLLVYLTDAN ANRLCPKSHL QGPPLNYVLL 720 LIGMMMARAE QTTVWLCGTG TVKTPVLTAD EGILKTAIKL QAQVQELEEN DEWPLETFEK 780 YLLSLAVRRT PIDRVILFGQ RMDTELLNVA KQIIWQHVNS KCLFVSVLLR KMQYMSPNLN 840 PNDVTLSGCT DGILKFIAEH GASRLLEHVG QLDKIFKIPP PPGKTKVSPL RPLEENNPGP 900 FVPISQHGWR NIRLFISSTF RDMHGERDLL MRSVLPALQA RAFPHRISLH AIDLRWGITE 960 EETRRNRQLE VCLGEVENSQ LFVGILGSRY GYTPPSYDLP DHPHFHWTQR YPSGRSVTEM 1020 EVMQFLNRGQ RSEPSDQALI YFRDPGFLSS VPDVWKPDFI SESEEAAHRV SELKRFLQEQ 1080 KEVTCRRYSC EWGGVAAGRP YTGGLEEFGQ LVLQDVWSVI QKRYLQPGAQ LEQPGSISEE 1140 DLIQASFQQL KSPPSPARPR LLQDTVQQLM LPHGRLSLVI GQAGQGKTAF LASLVSALKV 1200 PDQPNVAPFV FFHFSAARPD QCLAFNLLRR LCTHLHQKLG EPSALPSTYR GLVWELQQKL 1260 LLKSAQWLQP GQTLVLIIDG ADKLVDHNGQ LISDWIPKSL PRRVHLVLSV SSDSGLGETL 1320 QQSQSAYVVA LGSLVPSSRA QLVREELALY GKRLEESPFN NQMRLLLAKQ GSSLPLYLHL 1380 VTDYLRLFTL YEQVSERLRT LPATLPLLLQ HILSTLEQEH GHNVLPQALT ALEVTHSGLT 1440 VDQLHAVLST WLTLPKETKS WEEAVAASHS GNLYPLAPFA YLVQSLRSLL GEGPVERPGA 1500 RLCLSDGPLR TAVKRRYGKR LGLEKTAHVL IAAHLWKMCD PDASGTFRSC PPEALKDLPY 1560 HLLQSGNHGL LAKFLTNLHV VAAYLEVGLV PDLLEAYELY ASSKPEVNQK LPEADVAVFH 1620 NFLKQQASLL TQYPLLLLQQ AASQPEESPV CCQAPLLTQR WHNQCILKWI NKPQTLKGQQ 1680 SLSLPISSSP TAVAFSPNGQ RAAVGTAGGT IYLLNLRTWQ EEKALVSGCD GISSFAFLSD 1740 TALFLTTFDG LLELWDLQHG CWVFQTKAHQ YQITGCCLSP DRRLLATVCL GGYVKLWDTV 1800 QGQLAFQYTH PKSLNCITFH PEGQVVATGN WSGIVTFFQA DGLKVTKELG GPGPSVRTLA 1860 FSAPGKVVAL GRIDGTVELW AWQEGTRLAA FPAQCGGVST VLFLHAGGRF LTAGEDGKAQ 1920 LWSGFLGRPR GCLGSLYLSP ALSVALNPDG DQVAVGYRGD GIKIYRISSG PQEAQCQELN 1980 VAVSALVWLS PSVLVSGAED GSLHGWMLRR NSLQSLWLSS VCQKPVLGLA ASQEFLASAS 2040 EDFTVRLWPR QLLTQPHAVE ELPCAAELRG HEGPVCCCSF SPDGRILATA GRDRNLLCWD 2100 VKVAQAPLLI HTFSSCHRDW ITGCTWTKDN ILISCSSDGS VGLWNPEAGQ QLGQFPGHQS 2160 AVSAVVAVEE HIVSVSRDGT LKVWDRQGVE LTSIPAHSGP ISQCAAALEP RPAGQPGSEL 2220 MVVTVGLDGA TKLWHPLLVC QIHTLQGHSG PVTAAAASEA SGLLLTSDNS SVRLWQIPKE 2280 ADDTCKPRSS AVITAVAWAP DGSLVVSGNE AGELTLWQKA QAVATARAPG RVSDLIWCSA 2340 NAFFVLSANE NVSEWQVELR KGSTCTNFRL YLKRVLQEDL GVLTGMALAP DGQSLILMKE 2400 DVELLQMKPG STPSSICRRY AVHSSILCTS KDYGLFYLQQ GNSGSLSILE QEESGKFEKT 2460 LDFNLNLNNP NGSPVSITQA EPESGSSLLC ATSDGMLWNL SECTPEGEWV VDNIWQKKSR 2520 NPKSRTPGTD SSPGLFCMDS WVEPTHLKAR QCKKIHLGSV TALHVLPGLL VTASEDRDVK 2580 LWERPSMQLL GLFRCEGPVS CLEPWMEPSS PLQLAVGDAQ GNLYFLSWE |
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| Keyword | KW-0067--ATP-binding |
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| Interpro | IPR025139--DUF4062 |
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| PROSITE | PS50837--NACHT |
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| Pfam | |||||||||||||||||
| Gene Ontology | GO:0000781--C:chromosome, telomeric region |