| Tag |
Content |
| dbPAF ID |
dbPAF-0000308 |
| Uniprot Accession |
O08644; EPHB6_MOUSE; Q3TQ77; Q8BN76; Q8K0A9;
|
| Genbank Protein ID |
NP_001139823.1; NP_031706.3;
|
| Genbank Nucleotide ID |
NM_001146351.1; NM_007680.4;
|
| Protein Name |
Ephrin type-B receptor 6 |
| Protein Synonyms/Alias |
MEP;Tyrosine-protein kinase-defective receptor EPH-6; |
| Gene Name |
Ephb6 |
| Gene Synonyms/Alias |
Cekl; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity).Functional Description
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MATEGTTGSG SRVVAGMVCS LWLLVLGSSV LALEEVLLDT TGETSEIGWL TYPPGGWDEV 60
SVLDDQRRLT RTFEACHVAG LPPGSGQDNW LQTHFVERRG AQRAHIRLHF SVRACSSLGV 120
SGGTCRETFT LYYRQADEPD GPDSIAAWHL KRWTKVDTIA ADESFPASSS SSSWAVGPHR 180
TGQRVGLQLN VKERSFGPLT QRGFYVAFQD TGACLALVAV KLFSYTCPSV LRAFASFPET 240
QASGAGGASL VAAVGTCVAH AEPEEDGVGG QAGGSPPRLH CNGEGRWMVA VGGCRCQPGH 300
QPARGDKLCQ ACPEGSYKAL AGNVPCSPCP ARSHSPDPAA PVCPCLQGFY RASSDPPEAP 360
CTGPPSAPRE LWFEVQGSAL MLHWRLPQEL GGRGDLLFNV VCKECGGHGE PSSGGMCRRC 420
RDEVHFDPRQ RGLTESRVLV GGLRAHVPYI LEVQAVNGVS ELSPDPPQAA AINVSTSHEV 480
PSAVPVMHQV SRAANSITVS WPQPEQTNGN ILDYQLRYYD QAEDESHSFT MTSETNTATV 540
TRLSPGHIYG FQVRARTAAG HGPYGGKVYF QTLPQGELSS QLPEKLSLVI GSILGALAFL 600
LLAAITVLAV IFQRKRRGTG YTEQLQQYSS PGLGVKYYID PSTYDDPCQA IRELAREVDP 660
TYIKIEEVIG AGSFGEVRRG RLQPRGRREQ AVAIQALWAG GAESLKMTFL GRAALLGQFQ 720
HPNILRLEGV VTKSRPVMVL TELMELGPLD SFLRQREGQF SSLQLVAMQR GVAAAMQYLS 780
SFAFVHRALS ARSVLVNSHL VCKVARLGHS PQGSSSLLRW AAPEVITHGK YTTSSDVWSF 840
GILMWEVMSY GERPYWDMNE QEVLNAIEQE FRLPPPPGCP PGLHLLMLDT WQKDRARRPH 900
FDQLVAAFDK MIRKPDTLQA EGGSGDRPSQ ALLNPVALDF PCLDSPQAWL SAIGLECYQD 960
NFSKFGLSTF SDVAQLSLED LPGLGITLAG HQKKLLHNIQ LLQQHLRQPG SVEV
1015Fasta Sequence
>O08644|Ephb6|Mus musculus(Mouse)
MATEGTTGSGSRVVAGMVCSLWLLVLGSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQADEPDGPDSIAAWHLKRWTKVDTIAADESFPASSSSSSWAVGPHRTGQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYTCPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKALAGNVPCSPCPARSHSPDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRELWFEVQGSALMLHWRLPQELGGRGDLLFNVVCKECGGHGEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNILDYQLRYYDQAEDESHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSLVIGSILGALAFLLLAAITVLAVIFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYDDPCQAIRELAREVDPTYIKIEEVIGAGSFGEVRRGRLQPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLGHSPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAEGGSGDRPSQALLNPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLLQQHLRQPGSVEV
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR027936--Eph_TM
IPR001090--Ephrin_rcpt_lig-bd_dom
IPR003961--FN3_dom
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR001660--SAM
IPR013761--SAM/pointed
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR011641--Tyr-kin_ephrin_A/B_rcpt-like
IPR016257--Tyr_kinase_ephrin_rcpt
IPR001426--Tyr_kinase_rcpt_V_CS
|
| PROSITE |
PS51550--EPH_LBD
PS50853--FN3
PS50011--PROTEIN_KINASE_DOM
PS00790--RECEPTOR_TYR_KIN_V_1
PS00791--RECEPTOR_TYR_KIN_V_2
PS50105--SAM_DOMAIN
|
| Pfam |
PF14575--EphA2_TM
PF01404--Ephrin_lbd
PF00041--fn3
PF07699--GCC2_GCC3
PF07714--Pkinase_Tyr
PF07647--SAM_2
|
| Gene Ontology |
GO:0009986--C:cell surface
GO:0005576--C:extracellular region
GO:0005887--C:integral component of plasma membrane
GO:0005524--F:ATP binding
GO:0005003--F:ephrin receptor activity
GO:0050798--P:activated T cell proliferation
GO:0050663--P:cytokine secretion
GO:0032092--P:positive regulation of protein binding
GO:2000525--P:positive regulation of T cell costimulation
GO:0002456--P:T cell mediated immunity
GO:0001806--P:type IV hypersensitivity
|
