dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000306
Uniprot Accession O08638; MYH11_MOUSE; O08639; Q62462; Q64195;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Myosin-11
Protein Synonyms/Alias Myosin heavy chain 11;Myosin heavy chain, smooth muscle isoform;SMMHC;
Gene Name Myh11
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Muscle contraction.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
8MAQKGQLSDDEKFLFdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 19367708; 20415495; 21183079; 16381945; 23193290;
269ETYLLEKSRAIRQARcurated22817900
438RLFRWILSRVNKALDPhosphoSitePlus22135298
638MAKMTESSLPSASKTcurated21183079
1367QNLERHVSTLNIQLSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
1408MEGLSQQYEEKAAAYPhosphoSitePlus22135298
1518AEMEDLVSSKDDVGKPhosphoSitePlus22135298
1913ELDEATESNEAMGREdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
1951GRRVIENTDGSEEEMdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 21183079; 16381945; 23193290; 21081558; 19060867;
1954VIENTDGSEEEMDARdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17203969; 16381945; 23193290; 17242355; 19367708; 20415495;
1963EEMDARDSDFNGTKAPhosphoPep 2.019060867
1971DFNGTKASE------dbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298
Sequence
(Fasta)		MAQKGQLSDD EKFLFVDKNF MNSPMAQADW VAKKLVWVPS EKQGFEAASI KEEKGDEVVV 60
ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLRERYF SGLIYTYSGL 120
FCVVVNPYKY LPIYSEKIVD MYKGKKRHEM PPHIYAIADT AYRSMLQDRE DQSILCTGES 180
GAGKTENTQK VIQYLAVVAS SHKGKKDSSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS 240
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYLLAG AKEKMKSDLL 300
LESFNSYTFL SNGFVPIPAA QDDEMFQETL EAMSIMGFNE EEQLAILKVV SSVLQLGNIV 360
FKKERNTDQA SMPDNTAAQK VCHLVGINVT DFTRAILTPR IKVGRDVVQK AQTKEQADFA 420
IEALAKATYE RLFRWILSRV NKALDKTHRQ GASFLGILDI AGFEIFEVNS FEQLCINYTN 480
EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPSIE LIERPNNPPG VLALLDEECW 540
FPKATDKSFV EKLCSEQGNH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN 600
DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF RTVGQLYKEQ 660
LGKLMATLRN TTANFVRCII PNHEKRSGKL DAFLVLEQLR CNGVLEGIRI CRQGFPNRIV 720
FQEFRQRYEI LAANAIPKGF MDGKQACILM IKALELDPNL YRIGQSKIFF RTGVLAHLEE 780
ERDLKITDVI MAFQAMCRGY LARKAFTKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK 840
VKPLLQVTRQ EEEMQAKEEE MQKITERQQK AETELKELEQ KHTQLAEEKT LLQEQLQAET 900
ELYAESEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRRQQ LQAERKKMAQ QMLDLEEQLE 960
EEEAARQKLQ LEKVTAEAKI KKLEDDILVM DDQNSKLSKE RKLLEERVSD LTTNLAEEEE 1020
KAKNLTKLKS KHESMISELE VRLKKEEKSR QELEKLKRKL EGDASDFHEQ IADLQAQIAE 1080
LKMQLAKKEE ELQAALARLD EEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ 1140
KRDLGEELEA LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK 1200
HTQAVEELTE QLEQFKRAKA NLDKSKQTLE KENADLAGEL RVLGQAKQEV EHKKKKLEVQ 1260
LQDLQSKCSD GERARAELSD KVHKLQNEVE SVTGMLNEAE GKAIKLAKDV ASLGSQLQDT 1320
QELLQEETRQ KLNVSTKLRQ LEDERNSLQD QLDEEMEAKQ NLERHVSTLN IQLSDSKKKL 1380
QDFASTIEVM EEGKKRLQKE MEGLSQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR 1440
QLVSNLEKKQ KKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE 1500
ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE SEDDVQATED 1560
AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE YETELEDERK QRALAAAAKK 1620
KLEGDLKDLE LQADSAIKGR EEAIKQLRKL QAQMKDFQRE LDDARASRDE IFATSKENEK 1680
KAKSLEADLM QLQEDLAAAE RARKQADLEK EELAEELASS LSGRNTLQDE KRRLEARIAQ 1740
LEEELEEEQG NMEAMSDRVR KATLQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK 1800
LQEVEGAVKA KLKSTVAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK LKEVLLQVED 1860
ERKMAEQYKE QAEKGNTKVK QLKRQLEEAE EESQCINANR RKLQRELDEA TESNEAMGRE 1920
VNALKSKLRR GNEASFVPSR RAGGRRVIEN TDGSEEEMDA RDSDFNGTKA SE 1973
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0488--Methylation
KW-0505--Motor protein
KW-0514--Muscle protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0787--Thick filament
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR027401--Myosin-like_IQ_dom
IPR001609--Myosin_head_motor_dom
IPR004009--Myosin_N
IPR002928--Myosin_tail
IPR027417--P-loop_NTPase
PROSITE

PS50096--IQ
PS51456--MYOSIN_MOTOR
Pfam

PF00063--Myosin_head
PF02736--Myosin_N
PF01576--Myosin_tail_1
Gene Ontology

GO:0005903--C:brush border
GO:0070062--C:extracellular exosome
GO:0042470--C:melanosome
GO:0005859--C:muscle myosin complex
GO:0030016--C:myofibril
GO:0016459--C:myosin complex
GO:0032982--C:myosin filament
GO:0030485--C:smooth muscle contractile fiber
GO:0001725--C:stress fiber
GO:0005524--F:ATP binding
GO:0003774--F:motor activity
GO:0008307--F:structural constituent of muscle
GO:0048739--P:cardiac muscle fiber development
GO:0048251--P:elastic fiber assembly
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0030241--P:skeletal muscle myosin thick filament assembly
GO:0006939--P:smooth muscle contraction