dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000302
Uniprot Accession O08619; F13A_RAT;
Genbank Protein ID NP_067730.2;
Genbank Nucleotide ID NM_021698.2;
Protein Name Coagulation factor XIII A chain
Protein Synonyms/Alias
Gene Name F13a1
Gene Synonyms/Alias F13a;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
2------MSDTPATTFPhosphoSitePlus22135298
Sequence
(Fasta)		MSDTPATTFG GRGAIPPNNS NAAGVDLPTE DLQGLVPRGV SLKDYLNVTA VHLFKERWDS 60
NKIVHHTDKF DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF RVEYVIGRYP QENKGTYIPV 120
PVVTELQSGK WGAKVIMNED RSVRLSVQSS PECIVGKFRM YVAVWTPYGI LRTQRDPETD 180
TYILFNPWCE EDAVYLDDEK EREEYVLNDI GGIFHGDFND IKSRSWSYGQ FEDGILDACL 240
FVMDKAEMDL SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL 300
LEYRSSETPV RYGQCWVLAG VFNTFLRCLG IPARVITNYS SAHDNDANLQ MDIFLEEDGS 360
VSFKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP QENSDGMYRC GPASVQAVKH 420
GHVCFQFDAP FVLGEVNSDL VYITAKKDGT HVVENVDATH IGKLIVTKEI GGDGMQDITD 480
TYKFQEGQEE ERLALETALM YGAKKTLNTE GMVKSSSDVD MNFDVENAVL GKDFRVTITF 540
QNNSSNLYTI LAYLSGNITF YTGVSKKEFK TESFEVTLDP LSLEKKEVLI RAGEYMSYLL 600
EQGLLHFFVT ARINETRVVL AKQKAIVLTI PKVTIKVRGT AMVGSDMVVT VEFTNPLKET 660
LKNVWLHLEG PGVMRPKRKM FREIRPNATV QWEEVCQPWV SGHRKLNASM TSDSLRHVYG 720
ELDLQIRRRP TV 733
Keyword

KW-0012--Acyltransferase
KW-0094--Blood coagulation
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0325--Glycoprotein
KW-0356--Hemostasis
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0964--Secreted
KW-0808--Transferase
KW-0865--Zymogen
Interpro

IPR023608--Gln_gamma-glutamylTfrase_euk
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002931--Transglutaminase-like
IPR008958--Transglutaminase_C
IPR013808--Transglutaminase_CS
IPR001102--Transglutaminase_N
PROSITE

PS00547--TRANSGLUTAMINASES
Pfam

PF00927--Transglut_C
PF01841--Transglut_core
PF00868--Transglut_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0046872--F:metal ion binding
GO:0003810--F:protein-glutamine gamma-glutamyltransferase activity
GO:0007596--P:blood coagulation
GO:0018149--P:peptide cross-linking
GO:0042060--P:wound healing