dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000300
Uniprot Accession O08617; PTPRR_RAT; Q62695; Q63419;
Genbank Protein ID NP_001106861.1; NP_446046.2;
Genbank Nucleotide ID NM_001113390.1; NM_053594.2;
Protein Name Receptor-type tyrosine-protein phosphatase R
Protein Synonyms/Alias
Gene Name Ptprr
Gene Synonyms/Alias Ptp;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
323ASTSVCPSPFRMKPIcurated23589303
338GLQERRGSNVSLTLDPhosphoSitePlus22135298
Sequence
(Fasta)		MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP MFIYDHSQDI KKSLDIAQEA 60
YKHNYPAPSE VQISKRHQIV DSAFPRPAYD PSLNLLAASG QDLEIENLPI PAANVIVVTL 120
QMDIDKLNIT LLRIFRQGVA AALGLLPQQV HINRLIEKKS QIELFVSPGN RKPGEPQALQ 180
AEEVLRSLNV DVLRQSLPQF GSIDVSPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII 240
VTCLMIIYRL KERLQLSFRQ DKEKNQEIHL SPIALQQAQS EAKAAHSMVQ PDQAPKVLNV 300
VVDPQGQCTP EIRNTASTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG NVEPFVAVST 360
PREKVAMEYL QSASRVLTSP QLRDVVASSH LLQSEFMEIP MNFVDPKEID IPRHGTKNRY 420
KTILPNPLSR VCLRPKNITD PLSTYINANY IRGYSGKEKA FIATQGPMIN TVNDFWQMVW 480
QEDSPVIVMI TKLKEKNEKC VLYWPEKRGI YGKVEVLVIG VNECDNYTIR NLVLKRGSHT 540
QHVKHYWYTS WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT 600
SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL SPETVQ 657
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0904--Protein phosphatase
KW-0675--Receptor
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR029021--Prot-tyrosine_phosphatase-like
IPR000242--PTPase_domain
IPR016130--Tyr_Pase_AS
IPR008356--Tyr_Pase_KIM-con
IPR016334--Tyr_Pase_rcpt_R/non-rcpt_5
IPR000387--TYR_PHOSPHATASE_dom
PROSITE

PS00383--TYR_PHOSPHATASE_1
PS50056--TYR_PHOSPHATASE_2
PS50055--TYR_PHOSPHATASE_PTP
Pfam

PF00102--Y_phosphatase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0004725--F:protein tyrosine phosphatase activity
GO:0001701--P:in utero embryonic development
GO:0007399--P:nervous system development
GO:0030182--P:neuron differentiation
GO:0035335--P:peptidyl-tyrosine dephosphorylation