dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000299
Uniprot Accession O08609; MLX_MOUSE; Q9EQJ7; Q9EQJ8;
Genbank Protein ID NP_001152856.1; NP_001152857.1; NP_035680.3;
Genbank Nucleotide ID NM_001159384.1; NM_001159385.1; NM_011550.3;
Protein Name Max-like protein X
Protein Synonyms/Alias Max-like bHLHZip protein;Protein BigMax;Transcription factor-like protein 4;
Gene Name Mlx
Gene Synonyms/Alias Tcfl4;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
7-MTEPGASPEDPWVKcurated25266776; 20469934; 23984901
45RRGAPQLSPESPLLSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 16381945; 23193290; 18846507; 19854140; 20531401;
48APQLSPESPLLSGARdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 16381945; 23193290; 19854140; 20531401; 21183079;
74AKVEYAYSDNSLDPGcurated25338131
77EYAYSDNSLDPGLFVdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900;
110SASSVPNTDDEDSDYdbPTM 3.0;PhosphoSitePlus;curated17242355; 21183079; 16381945; 23193290; 22135298
115PNTDDEDSDYQQEAYdbPTM 3.0;PhosphoSitePlus17242355; 21183079; 16381945; 23193290; 22135298
117TDDEDSDYQQEAYKEPhosphoSitePlus22135298
206STLRKDVTALKIMKVdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MTEPGASPED PWVKASFADA HAGEGRAGRA RARRGSGRRG APQLSPESPL LSGARGCRED 60
SSHPACAKVE YAYSDNSLDP GLFVESTHKG SVVSRANSIG STSASSVPNT DDEDSDYQQE 120
AYKESYKDRR RRAHTQAEQK RRDAIKRGYD DLQTIVPTCQ QQDFSIGSQK LSKAIVLQKT 180
IDYIQFLHKE KKKQEEEVST LRKDVTALKI MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN 240
VFQGIMDSLF QSFNASISVA SFQELSACVF SWIEEHCEPQ TLREIVIGVL HQLKNQLY 299
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR011598--bHLH_dom
IPR032647--Mlx
PROSITE

PS50888--BHLH
Pfam

PF00010--HLH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006913--P:nucleocytoplasmic transport
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated