dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000298
Uniprot Accession O08608; OAZ2_MOUSE;
Genbank Protein ID NP_035082.1;
Genbank Nucleotide ID NM_010952.3;
Protein Name Ornithine decarboxylase antizyme 2
Protein Synonyms/Alias
Gene Name Oaz2
Gene Synonyms/Alias Sez15;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:16916800, PubMed:18508777, PubMed:24967154). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
186YPLDQNLSDED----dbPTM 3.0;PhosphoSitePlus;UniProt19725046; 16381945; 23193290; 22135298
Sequence
(Fasta)		MINTQDSSIL PLSKCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD 60
EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL 120
ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP 180
LDQNLSDED
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0620--Polyamine biosynthesis
KW-1185--Reference proteome
KW-0688--Ribosomal frameshifting
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR029916--ODC-AZ_2
IPR002993--ODC_AZ
PROSITE

PS01337--ODC_AZ
Pfam

PF02100--ODC_AZ
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0008073--F:ornithine decarboxylase inhibitor activity
GO:1902268--P:negative regulation of polyamine transmembrane transport
GO:0006596--P:polyamine biosynthetic process
GO:0006595--P:polyamine metabolic process
GO:0090316--P:positive regulation of intracellular protein transport
GO:0045732--P:positive regulation of protein catabolic process